Literature DB >> 6957371

Fibrinogen gamma chain locus is on chromosome 4 in man.

B Olaisen, P Teisberg, T Gedde-Dahl.   

Abstract

A molecular fibrinogen variant has been detected by two-dimensional electrophoresis of human plasma samples. Fibrinogen is a complex molecule consisting of three different polypeptide chains A alpha, B beta, and gamma. The presently described variation resides in the gamma-chain, which in the variant is slightly more basic and heavier than the common form of this chain. In a family material it has been shown that the variant is genetically determined, and the segregation pattern shows autosomal codominant inheritance. The family material has been typed in approximately 30 marker systems, and linkage studies have shown close linkage between the gamma-chain locus (FGG) and MNSs. The MNSs loci are known to be located on chromosome 4 in humans and the fibrinogen gamma-chain locus is thus on this chromosome. The MNSs/FGG distance is approximately 8 centimorgans. Supplementing data suggest that FGG is distal to MNSs on the long arm of chromosome 4.

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Year:  1982        PMID： 6957371     DOI： 10.1007/bf00291325

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  14 in total

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Journal:  Am J Hum Genet       Date:  1955-09       Impact factor: 11.025

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Journal:  Blut       Date:  1976-10

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Journal:  Thromb Diath Haemorrh       Date:  1973-06-28

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Authors:  A Z Budzynski; V J Marder; D Ménaché; M C Guillin
Journal:  Nature       Date:  1974-11-01       Impact factor: 49.962

Review 7.  Report of the committee on the genetic constitution of chromosomes 2, 3, 4, and 5.

Authors:  D Bootsma; P J McAlpine
Journal:  Cytogenet Cell Genet       Date:  1979

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Authors:  M W Mosesson; J S Finlayson; R A Umfleet
Journal:  J Biol Chem       Date:  1972-08-25       Impact factor: 5.157

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Authors:  B Kudryk; B Blombäck; M Blombäck
Journal:  Thromb Res       Date:  1976-07       Impact factor: 3.944

10.  Human plasma fibrinogen heterogeneity: evidence for an extended carboxyl-terminal sequence in a normal gamma chain variant (gamma').

Authors:  C Wolfenstein-Todel; M W Mosesson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205
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  9 in total

1.  Pairwise linkage analysis of 11 loci on human chromosome 4.

Authors:  J C Murray; K H Buetow; M Smith; L Carlock; A Chakravarti; R F Ferrell; L Gedamu; C Gilliam; R Shiang; C R DeHaven
Journal:  Am J Hum Genet       Date:  1988-03       Impact factor: 11.025

2.  The association of combined alpha and beta fibrinogen genotype on plasma fibrinogen levels in smokers and non-smokers.

Authors:  A E Thomas; F R Green; H Lamlum; S E Humphries
Journal:  J Med Genet       Date:  1995-08       Impact factor: 6.318

3.  The identification of a DNA polymorphism of the alpha fibrinogen gene, and the regional assignment of the human fibrinogen genes to 4q26-qter.

Authors:  S E Humphries; A M Imam; T P Robbins; M Cook; B Carritt; C Ingle; R Williamson
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

4.  Two-dimensional gel studies of genetic variation in the plasma proteins of Amerindians and Japanese.

Authors:  J Asakawa; N Takahashi; B B Rosenblum; J V Neel
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

5.  Linkage studies between polymorphic markers on chromosome 4 and cystic fibrosis.

Authors:  P Scambler; T Robbins; C Gilliam; A Boylston; P Tippett; R Williamson; K E Davies
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

6.  Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion.

Authors:  J A Kant; A J Fornace; D Saxe; M I Simon; O W McBride; G R Crabtree
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

7.  The genes coding for A alpha-, B beta-, and gamma-chains of fibrinogen map to 4q2.

Authors:  I Henry; G Uzan; D Weil; H Nicolas; J C Kaplan; C Marguerie; A Kahn; C Junien
Journal:  Am J Hum Genet       Date:  1984-07       Impact factor: 11.025

8.  Twenty-seven protein polymorphisms by two-dimensional electrophoresis of serum, erythrocytes, and fibroblasts in two pedigrees.

Authors:  D Goldman; L R Goldin; P Rathnagiri; S J O'Brien; J A Egeland; C R Merril
Journal:  Am J Hum Genet       Date:  1985-09       Impact factor: 11.025

9.  Linkage disequilibrium relationships among four polymorphisms within the human fibrinogen gene cluster.

Authors:  R E Baumann; A H Henschen
Journal:  Hum Genet       Date:  1994-08       Impact factor: 4.132
  9 in total

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