Literature DB >> 1683409

The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5.

S Rogne1, O Myklebost, J H Olving, H T Kyrkjebø, R Jonassen, B Olaisen, T Gedde-Dahl.   

Abstract

We have used a cDNA probe for human complement component 9 (C9), which detects three DNA polymorphisms, to analyse the inheritance of C9 in families informative for C6 protein variants. We found that these genes are closely linked with a lod score of 9.28 at recombination fraction 0.00. There is not indication of allelic association.

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Year:  1991        PMID： 1683409      PMCID： PMC1015787          DOI： 10.1136/jmg.28.9.587

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  21 in total

1.  Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6.

Authors:  P Teisberg; I Akesson; B Olaisen; T Gedde-Dahl; E Thorsby
Journal:  Nature       Date:  1976-11-18       Impact factor: 49.962

2.  The assignment of the genes coding for human complement components C6 and C7 to chromosome 5.

Authors:  S J Jeremiah; C M Abbott; Z Murad; S Povey; H J Thomas; E Solomon; R G DiScipio; G H Fey
Journal:  Ann Hum Genet       Date:  1990-05       Impact factor: 1.670

3.  Multiple RFLPs of human complement component nine (C9) detected by TaqI.

Authors:  S Rogne; B Mevåg; T Gedde-Dahl; O Myklebost
Journal:  Nucleic Acids Res       Date:  1990-05-25       Impact factor: 16.971

4.  Nonlinkage between C6 and chromosome 6 markers.

Authors:  J H Olving; B Olaisen; P Teisberg; T Gedde-Dahl; E Thorsby
Journal:  Hum Genet       Date:  1977-06-30       Impact factor: 4.132

Review 5.  Report of the Committee on Human Gene Mapping by Recombinant DNA Techniques.

Authors:  M H Skolnick; H F Willard; L A Menlove
Journal:  Cytogenet Cell Genet       Date:  1984

6.  Inherited structural variation and linkage relationships of C7.

Authors:  M J Hobart; V Joysey; P J Lachmann
Journal:  J Immunogenet       Date:  1978-06

7.  Assignment of the structural gene for the third component of human complement to chromosome 19.

Authors:  A S Whitehead; E Solomon; S Chambers; W F Bodmer; S Povey; G Fey
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

8.  Genetic linkage relations of the sixth component of complement (C6).

Authors:  J H Olving; B Olaisen; T Gedde-Dahl; P Teisberg
Journal:  Hum Genet       Date:  1979-01-25       Impact factor: 4.132

9.  Combined genetic deficiency of C6 and C7 in man.

Authors:  P J Lachmann; M J Hobart; P Woo
Journal:  Clin Exp Immunol       Date:  1978-08       Impact factor: 4.330

10.  Hereditary C2 deficiency: Genetic studies and association with the HL-A system.

Authors:  N K Day; R L'Esperance; R A Good; A F Michael; J A Hansen; B Dupont; C Jersild
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307
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  2 in total

1.  A physical map of the human complement component C6, C7, and C9 genes.

Authors:  F Setién; V Alvarez; E Coto; R G DiScipio; C López-Larrea
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846

2.  C7 M/N protein polymorphism typing applied to inherited deficiencies of human complement proteins C6 and C7.

Authors:  R Würzner; N Rance; P C Potter; M L Hendricks; P J Lachmann; A Orren
Journal:  Clin Exp Immunol       Date:  1992-09       Impact factor: 4.330
  2 in total

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