Literature DB >> 6414458

UDP-glucuronyltransferase activity exhibits two developmental groups in liver from foetal rhesus monkeys.

J E Leakey, Z R Althaus, J R Bailey, W Slikker.   

Abstract

UDP-glucuronyltransferase was assayed in liver from adult rhesus monkeys and foetuses during late gestation. Activities toward 2-aminophenol, 5-hydroxytryptamine, 1-naphthol and 4-nitrophenol in the foetal liver ranged from 46 to 114% of adult values, whereas activities toward bilirubin, oestradiol and testosterone were less than 5% of adult values. This suggests that in primates UDP-glucuronyltransferase develops differentially in two clusters analogous to that in the rat.

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Year:  1983        PMID： 6414458      PMCID： PMC1152346          DOI： 10.1042/bj2141007

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates.

Authors:  G J Wishart
Journal:  Biochem J       Date:  1978-08-15       Impact factor: 3.857

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  An improved assay for steroid glucuronyltransferase in rat liver microsomes.

Authors:  G S Rao; G Haueter; M L Rao; H Breuer
Journal:  Anal Biochem       Date:  1976-07       Impact factor: 3.365

4.  Relationship beteen activation of "detoxicating" enzymes in stored broken-cell preparations and in autolysing liver.

Authors:  B Burchell; J Leakey; G J Dutton
Journal:  Enzyme       Date:  1975

5.  Assays for UDPglucuronyltransferase activities.

Authors:  G J Dutton; J E Leakey; M R Pollard
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

Review 6.  The perinatal development of drug-metabolizing enzymes: what factors trigger their onset?

Authors:  G J Dutton; J E Leakey
Journal:  Prog Drug Res       Date:  1981

7.  An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme.

Authors:  J E Leakey
Journal:  Biochem J       Date:  1978-12-01       Impact factor: 3.857

8.  Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.

Authors:  S Onishi; N Kawade; S Itoh; K Isobe; S Sugiyama
Journal:  Biochem J       Date:  1979-12-15       Impact factor: 3.857

9.  Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor.

Authors:  F P Van Roy; K P Heirwegh
Journal:  Biochem J       Date:  1968-04       Impact factor: 3.857

10.  Placental transfer and metabolism of 17 alpha-ethynylestradiol-17 beta and estradiol-17 beta in the rhesus monkey.

Authors:  W Slikker; J R Bailey; D Newport; G W Lipe; D E Hill
Journal:  J Pharmacol Exp Ther       Date:  1982-11       Impact factor: 4.030
  10 in total
  2 in total

1.  Development of multiple activities of UDP-glucuronyltransferase in human liver.

Authors:  J E Leakey; R Hume; B Burchell
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

2.  Dexamethasone increases UDP-glucuronyltransferase activity towards bilirubin, oestradiol and testosterone in foetal liver from rhesus monkey during late gestation.

Authors:  J E Leakey; Z R Althaus; J R Bailey; W Slikker
Journal:  Biochem J       Date:  1985-01-01       Impact factor: 3.857
  2 in total

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