Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Development of multiple activities of UDP-glucuronyltransferase in human liver.

Literature DB >> 3117034

Development of multiple activities of UDP-glucuronyltransferase in human liver.

Abstract

UDP-glucuronyltransferase activities towards eight substrates were assayed in samples of foetal, term and adult human liver. Activities towards bilirubin, androsterone, testosterone, 1-naphthol, 4-nitrophenol and 2-aminophenol were present in foetal and term liver samples at less than 14% of adult values, whereas activity towards 5-hydroxytryptamine was present in foetal and term liver at 109 and 121% of adult values respectively. Thus a 'foetal' form of UDP-glucuronyltransferase may exist in human liver that is more restricted in substrate specificity than are those of the rat or rhesus monkey.

Entities: Chemical Species

Mesh：

Substances：

Year: 1987 PMID： 3117034 PMCID： PMC1147936 DOI： 10.1042/bj2430859

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

20 in total

1. Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates.

Authors: G J Wishart
Journal: Biochem J Date: 1978-08-15 Impact factor: 3.857

2. UDP-glucuronyltransferase in perfused rat liver and in microsomes - III. Effects of galactosamine and carbon tetrachloride on the glucuronidation of 1-naphthol and bilirubin.

Authors: G Otani; M M Abou-El-Makarem; K W Bock
Journal: Biochem Pharmacol Date: 1976-06-01 Impact factor: 5.858

3. An improved assay for steroid glucuronyltransferase in rat liver microsomes.

Authors: G S Rao; G Haueter; M L Rao; H Breuer
Journal: Anal Biochem Date: 1976-07 Impact factor: 3.365

4. Isolation and purification of bilirubin UDP-glucuronyl-transferase from rat liver.

Authors: B Burchell
Journal: FEBS Lett Date: 1980-02-25 Impact factor: 4.124

5. An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme.

Authors: J E Leakey
Journal: Biochem J Date: 1978-12-01 Impact factor: 3.857

6. Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.

Authors: S Onishi; N Kawade; S Itoh; K Isobe; S Sugiyama
Journal: Biochem J Date: 1979-12-15 Impact factor: 3.857

7. Separation, purification, and characterization of digitoxigenin-monodigitoxoside UDP-glucuronosyltransferase activity.

Authors: L von Meyerinck; B L Coffman; M D Green; R B Kirkpatrick; A Schmoldt; T R Tephly
Journal: Drug Metab Dispos Date: 1985 Nov-Dec Impact factor: 3.922

8. Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor.

Authors: F P Van Roy; K P Heirwegh
Journal: Biochem J Date: 1968-04 Impact factor: 3.857

9. Steroid and non-steroid UDP glucuronyltransferase: glucuronidation of synthetic estrogens as steroids.

Authors: G W Lucier; O S McDaniel
Journal: J Steroid Biochem Date: 1977-08 Impact factor: 4.292

10. Detection, purification and characterization of a human cancer-associated galactosyltransferase acceptor.

Authors: D K Podolsky; M M Weiser
Journal: Biochem J Date: 1979-02-15 Impact factor: 3.857

25 in total

Review 1. Glucuronidation in humans. Pharmacogenetic and developmental aspects.

Authors: S N de Wildt; G L Kearns; J S Leeder; J N van den Anker
Journal: Clin Pharmacokinet Date: 1999-06 Impact factor: 6.447

2. Uridine 5'-diphosphoglucuronic acid (UDPGLcUA) in the human fetal liver, kidney and placenta.

Authors: M Cappiello; L Giuliani; A Rane; G M Pacifici
Journal: Eur J Drug Metab Pharmacokinet Date: 2000 Jul-Dec Impact factor: 2.441

Review 3. Fetal drug metabolism and its possible clinical implications.

Authors: B Krauer; P Dayer
Journal: Clin Pharmacokinet Date: 1991-07 Impact factor: 6.447

4. Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I.

Authors: H H van Es; B G Goldhoorn; M Paul-Abrahamse; R P Elferink; P L Jansen
Journal: J Clin Invest Date: 1990-04 Impact factor: 14.808