Literature DB >> 6413975

Membership mutation of the genetic code: loss of fitness by tryptophan.

J T Wong.   

Abstract

Bacillus subtilis strain QB928, a tryptophan-auxotroph, was serially mutated to yield strain HR15. For QB928, tryptophan functioned as a competent amino acid and 4-fluorotryptophan as merely an inferior analogue. For HR15, these roles were reversed. The tryptophan/4-fluorotryptophan growth ratio decreased by a factor of 2 X 10(4) in the transition from QB928 to HR15.

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Year:  1983        PMID： 6413975      PMCID： PMC394285          DOI： 10.1073/pnas.80.20.6303

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

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