Literature DB >> 6369316

Thymosin alpha 11: a peptide related to thymosin alpha 1 isolated from calf thymosin fraction 5.

J Caldarella, G J Goodall, A M Felix, E P Heimer, S B Salvin, B L Horecker.   

Abstract

Two peptides related to thymosin alpha 1 have been isolated from preparations of calf thymosin fraction 5. One, lacking four amino acid residues at the COOH terminus, is designated des-(25-28)-thymosin alpha 1. The other, named thymosin alpha 11, contains seven additional amino acid residues at the COOH terminus. The sequence of this peptide is: AcSer-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu- Lys-Glu-Lys- Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-Arg-Glu-Ala-Pro-Ala-AsnOH. Thymosin alpha 11, in doses of less than 300 ng per mouse, protects susceptible inbred murine strains against opportunistic infections with Candida albicans. It is approximately equal to 30 times as potent as thymosin fraction 5 and approximately equal in potency to thymosin alpha 1.

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Year:  1983        PMID： 6369316      PMCID： PMC389963          DOI： 10.1073/pnas.80.24.7424

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus.

Authors:  T L Low; G B Thurman; M McAdoo; J McClure; J L Rossio; P H Naylor; A L Goldstein
Journal:  J Biol Chem       Date:  1979-02-10       Impact factor: 5.157

2.  Purification and properties of bovine thymosin.

Authors:  J A Hooper; M C McDaniel; G B Thurman; G H Cohen; R S Schulof; A L Goldstein
Journal:  Ann N Y Acad Sci       Date:  1975-02-28       Impact factor: 5.691

3.  Modification of fructose bisphosphatase by a proteolytic enzyme from rat liver lysosomes.

Authors:  P S Lazo; O Tsolas; S C Sun; S Pontremoli; B L Horecker
Journal:  Arch Biochem Biophys       Date:  1978-06       Impact factor: 4.013

4.  Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.

Authors:  A L Goldstein; T L Low; M McAdoo; J McClure; G B Thurman; J Rossio; C Y Lai; D Chang; S S Wang; C Harvey; A H Ramel; J Meienhofer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

5.  Purification and biological activity of thymosin, a hormone of the thymus gland.

Authors:  A L Goldstein; A Guha; M M Zatz; M A Hardy; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

6.  Translation of mRNA from calf thymus in the wheat germ system: evidence for a precursor of thymosin alpha1.

Authors:  M Freire; O Crivellaro; C Isaacs; J Moschera; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

7.  Purification of thymus mRNA coding for a 16,000-dalton polypeptide containing the thymosin alpha 1 sequence.

Authors:  M Freire; E Hannappel; M Rey; J M Freire; H Kido; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

8.  A gas-liquid solid phase peptide and protein sequenator.

Authors:  R M Hewick; M W Hunkapiller; L E Hood; W J Dreyer
Journal:  J Biol Chem       Date:  1981-08-10       Impact factor: 5.157

9.  Solid-phase synthesis of thymosin alpha 1 using tert-butyloxycarbonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-resin.

Authors:  T W Wong; R B Merrifield
Journal:  Biochemistry       Date:  1980-07-08       Impact factor: 3.162

10.  Maturational effects of thymic hormones on human helper and suppressor T cells: effects of FTS ('Facteur Thymique Sérique') and thymosin.

Authors:  D B Kaufman
Journal:  Clin Exp Immunol       Date:  1980-03       Impact factor: 4.330
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  12 in total

1.  Properties of the protein kinase that phosphorylates prothymosin alpha.

Authors:  A Peréz-Estévez; J Freire; C Sarandeses; G Covelo; C Díaz-Jullien; M Freire
Journal:  Mol Cell Biochem       Date:  2000-05       Impact factor: 3.396

2.  Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ.

Authors:  M Clinton; L Graeve; H el-Dorry; E Rodriguez-Boulan; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

3.  Synthesis and apparent secretion of prothymosin alpha by different subpopulations of calf and rat thymocytes.

Authors:  F J Franco; C Diaz; M Barcia; P Arias; J Gomez-Marquez; F Soriano; E Mendez; M Freire
Journal:  Immunology       Date:  1989-06       Impact factor: 7.397

4.  Multiple sclerosis: II. Effects of prothymosin alpha on the autologous and allogeneic MLR in patients with multiple sclerosis.

Authors:  G J Reclos; C N Baxevanis; C Sfagos; C Papageorgiou; G C Tsokos; M Papamichail
Journal:  Clin Exp Immunol       Date:  1987-11       Impact factor: 4.330

5.  Preparations of homeostatic thymus hormone consist predominantly of histones 2A and 2B and suggest additional histone functions.

Authors:  R Reichhart; M Zeppezauer; H Jörnvall
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

6.  Primary structure of rat thymus prothymosin alpha.

Authors:  A A Haritos; R Blacher; S Stein; J Caldarella; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

Review 7.  Thymosins and anti-thymosins: properties and clinical applications.

Authors:  A L Goldstein; R S Schulof; P H Naylor; N R Hall
Journal:  Med Oncol Tumor Pharmacother       Date:  1986

8.  Prothymosin alpha: isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus.

Authors:  A A Haritos; G J Goodall; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

9.  Distribution of prothymosin alpha in rat tissues.

Authors:  A A Haritos; O Tsolas; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

10.  Parathymosin alpha: a peptide from rat tissues with structural homology to prothymosin alpha.

Authors:  A A Haritos; S B Salvin; R Blacher; S Stein; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205
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