Literature DB >> 3856246

Parathymosin alpha: a peptide from rat tissues with structural homology to prothymosin alpha.

A A Haritos, S B Salvin, R Blacher, S Stein, B L Horecker.   

Abstract

A peptide, parathymosin alpha, containing approximately equal to 105 amino acid residues, has been isolated from rat thymus, and the sequence of the first 30 residues at the NH2 terminus has been determined. In this region, it shows 43% structural identity with thymosin alpha 1 and prothymosin alpha. The common sequences do not include residues 2-9, which accounts for the poor reactivity of parathymosin alpha with an antibody directed against this epitope in thymosin alpha 1. Parathymosin alpha appears to modulate the action of prothymosin alpha in protecting sensitive strains of mice against opportunistic infection with Candida albicans.

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Year:  1985        PMID： 3856246      PMCID： PMC397191          DOI： 10.1073/pnas.82.4.1050

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus.

Authors:  T L Low; G B Thurman; M McAdoo; J McClure; J L Rossio; P H Naylor; A L Goldstein
Journal:  J Biol Chem       Date:  1979-02-10       Impact factor: 5.157

2.  Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.

Authors:  A L Goldstein; T L Low; M McAdoo; J McClure; G B Thurman; J Rossio; C Y Lai; D Chang; S S Wang; C Harvey; A H Ramel; J Meienhofer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

3.  Primary structure of rat thymus prothymosin alpha.

Authors:  A A Haritos; R Blacher; S Stein; J Caldarella; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

4.  Cytosolic Ca2+-dependent neutral proteinases from rabbit liver: activation of the proenzymes by Ca2+ and substrate.

Authors:  S Pontremoli; E Melloni; F Salamino; B Sparatore; M Michetti; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

5.  Immunochemical studies on thymosin: radioimmunoassay of thymosin alpha 1.

Authors:  J E McClure; N Lameris; D W Wara; A L Goldstein
Journal:  J Immunol       Date:  1982-01       Impact factor: 5.422

6.  Thymosin beta 10, a new analog of thymosin beta 4 in mammalian tissues.

Authors:  S Erickson-Viitanen; S Ruggieri; P Natalini; B L Horecker
Journal:  Arch Biochem Biophys       Date:  1983-09       Impact factor: 4.013

7.  Distribution of prothymosin alpha in rat tissues.

Authors:  A A Haritos; O Tsolas; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

8.  Thymosin alpha 11: a peptide related to thymosin alpha 1 isolated from calf thymosin fraction 5.

Authors:  J Caldarella; G J Goodall; A M Felix; E P Heimer; S B Salvin; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

9.  Resistance and susceptibility to infection in inbred murine strains. I. Variations in the response to thymic hormones in mice infected with Candida albicans.

Authors:  S B Salvin; R Neta
Journal:  Cell Immunol       Date:  1983-01       Impact factor: 4.868
  9 in total
  15 in total

1.  Evidence for the extranuclear localization of thymosins in thymus.

Authors:  O E Tsitsiloni; P P Yialouris; H Echner; W Voelter; A A Haritos
Journal:  Experientia       Date:  1992-04-15

2.  Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ.

Authors:  M Clinton; L Graeve; H el-Dorry; E Rodriguez-Boulan; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

3.  Promotion of murine antitumor activity by prothymosin alpha treatment: I. Induction of tumoricidal peritoneal cells producing high levels of tumour necrosis factor alpha.

Authors:  M Papanastasiou; C N Baxevanis; M Papamichail
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

4.  Multiple sclerosis: II. Effects of prothymosin alpha on the autologous and allogeneic MLR in patients with multiple sclerosis.

Authors:  G J Reclos; C N Baxevanis; C Sfagos; C Papageorgiou; G C Tsokos; M Papamichail
Journal:  Clin Exp Immunol       Date:  1987-11       Impact factor: 4.330

5.  Boosting immune response to hepatitis B DNA vaccine by coadministration of Prothymosin alpha-expressing plasmid.

Authors:  Yanwen Jin; Cheng Cao; Ping Li; Xuan Liu; Wei Huang; Chufang Li; Qingjun Ma
Journal:  Clin Diagn Lab Immunol       Date:  2005-12

6.  Prothymosin alpha is not a nuclear polypeptide.

Authors:  O E Tsitsiloni; P P Yialouris; K Sekeri-Pataryas; A A Haritos
Journal:  Experientia       Date:  1989-04-15

7.  Prothymosin-α and parathymosin expression predicts poor prognosis in squamous and adenosquamous carcinomas of the gallbladder.

Authors:  Kang Chen; Li Xiong; Zhuling Yang; Shengfu Huang; Rong Zeng; Xiongying Miao
Journal:  Oncol Lett       Date:  2018-01-19       Impact factor: 2.967

8.  Induction of tumor-specific T lymphocyte responses in vivo by prothymosin alpha.

Authors:  C N Baxevanis; A D Gritzapis; G Spanakos; O E Tsitsilonis; M Papamichail
Journal:  Cancer Immunol Immunother       Date:  1995-06       Impact factor: 6.968

9.  Age- and sex-related differences in the content of prothymosin alpha in rat tissues.

Authors:  S Frillingos; O Tsolas
Journal:  Experientia       Date:  1992-03-15

10.  Induction of lymphokine-activated killer activity in mice by prothymosin alpha.

Authors:  C N Baxevanis; A D Gritzapis; G V Dedoussis; N G Papadopoulos; O Tsolas; M Papamichail
Journal:  Cancer Immunol Immunother       Date:  1994-04       Impact factor: 6.968
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