Literature DB >> 4505657

Purification and biological activity of thymosin, a hormone of the thymus gland.

A L Goldstein, A Guha, M M Zatz, M A Hardy, A White.   

Abstract

The purification and chemical properties of thymosin, obtained from bovine thymus tissue, are described. The biological activity of the thymic hormone has been assessed by a newly developed rosette assay, which permits measurement of thymus-dependent lymphoid cells. Thymosin activity is associated with a physico-chemically homogeneous protein of molecular weight 12,600. The hormonal activity is evident in in vitro incubation assay, after injection into adult thymectomized mice, and in prolonging survival of neonatally thymectomized mice and the reconstitution of their response to a skin allograft.

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Year:  1972        PMID： 4505657      PMCID： PMC426805          DOI： 10.1073/pnas.69.7.1800

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Ontogenesis of cell-mediated immunity in murine thymocytes and spleen cells and its acceleration by thymosin, a thymic hormone.

Authors:  A L Goldstein; A Guha; M L Howe; A White
Journal:  J Immunol       Date:  1971-03       Impact factor: 5.422

2.  Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone.

Authors:  J F Bach; M Dardenne; A L Goldstein; A Guha; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

Review 3.  The thymus as an endocrine gland: properties of thymosin, a new thymus hormone.

Authors:  A L Goldstein; Y Asanuma; A White
Journal:  Recent Prog Horm Res       Date:  1970

4.  Reduction in the incidence of wasting disease in neonatally thymectomized CBA-W mice by the injection of thymosin.

Authors:  Y Asanuma; A L Goldstein; A White
Journal:  Endocrinology       Date:  1970-03       Impact factor: 4.736

5.  Influence of thymosin on cell-mediated and humoral immune responses in normal and in immunologically deficient mice.

Authors:  A L Goldstein; Y Asanuma; J R Battisto; M A Hardy; J Quint; A White
Journal:  J Immunol       Date:  1970-02       Impact factor: 5.422

Review 6.  Current concepts of the immunological function of the thymus.

Authors:  J F Miller; D Osoba
Journal:  Physiol Rev       Date:  1967-07       Impact factor: 37.312

7.  Influence of thymosin on immunological competence of lymphoid cells from thymectomized mice.

Authors:  L W Law; A L Goldstein; A White
Journal:  Nature       Date:  1968-09-28       Impact factor: 49.962

8.  Early affect of adult thymectomy.

Authors:  J F Bach; M Dardenne; A J Davies
Journal:  Nat New Biol       Date:  1971-05-26

9.  Acceleration by thymosin of the development of resistance to murine sarcoma virus-induced tumor in mice.

Authors:  M Zisblatt; A L Goldstein; F Lilly; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1970-08       Impact factor: 11.205

10.  Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin).

Authors:  A L Goldstein; F D Slater; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1966-09       Impact factor: 11.205
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  61 in total

1.  In vitro differentiation of human marrow cells into T lymphocytes by thymic extracts using the rosette technique.

Authors:  G S Incefy; P L'Esperance; R A Good
Journal:  Clin Exp Immunol       Date:  1975-03       Impact factor: 4.330

2.  Immunodeficiency diseases. I. T-lymphocyte precursors and T-lymphocyte differentiation in partial Di George syndrome.

Authors:  J L Touraine; F Touraine; J Dutruge; J Gilly; S Colon; R Gilly
Journal:  Clin Exp Immunol       Date:  1975-07       Impact factor: 4.330

3.  Differentiation of population of peripheral blood lymphocytes into cells bearing sheep erythrocyte receptors in vitro by human thymic extract.

Authors:  J E Vogel; G S Incefy; R A Good
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

4.  In vitro culture of functional human thymic epithelium.

Authors:  M Papiernik; B Nabarra; J F Bach
Journal:  Clin Exp Immunol       Date:  1975-02       Impact factor: 4.330

5.  Thymus lymphocytes in uraemic rats and the effect of thymosin fraction 5 in vitro.

Authors:  S Ikemoto; T Kishimoto; S Wada; N Hayahara; M Maekawa
Journal:  Clin Exp Immunol       Date:  1990-06       Impact factor: 4.330

6.  Serum thymosin α 1 levels in patients with chronic inflammatory autoimmune diseases.

Authors:  F Pica; M S Chimenti; R Gaziano; C Buè; I A Casalinuovo; P Triggianese; P Conigliaro; D Di Carlo; V Cordero; G Adorno; A Volpi; R Perricone; E Garaci
Journal:  Clin Exp Immunol       Date:  2016-08-01       Impact factor: 4.330

7.  Combination therapy with thymosin alpha1 and dexamethasone helps mice survive sepsis.

Authors:  Xiao-song Xiang; Ning Li; Yun-zhao Zhao; Qiu-rong Li; Jie-shou Li
Journal:  Inflammation       Date:  2014-04       Impact factor: 4.092

8.  In vitro induction of monoclonal antibody-defined T-cell markers in lymphocytes from immunodeficient children by synthetic serum thymic factor (FTS).

Authors:  M C Bene; G Faure; P Bordigoni; D Olive; J Duheille
Journal:  Clin Exp Immunol       Date:  1982-05       Impact factor: 4.330

9.  Thymosins beta 8 and beta 9: two new peptides isolated from calf thymus homologous to thymosin beta 4.

Authors:  E Hannappel; S Davoust; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

10.  [Comparative study of the effect of thymosin and supernatant from epithelial thymic cells on antibody production (author's transl)].

Authors:  P Deschaux; R Fontanges; A Goldstein
Journal:  Experientia       Date:  1979-05-15
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