Literature DB >> 265536

Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.

A L Goldstein, T L Low, M McAdoo, J McClure, G B Thurman, J Rossio, C Y Lai, D Chang, S S Wang, C Harvey, A H Ramel, J Meienhofer.   

Abstract

The amino acid sequence of a biologically active polypeptide isolated from calf thymus, termed thymosin alpha1, has been determined. Thymosin alpha1 is a heat stable, highly acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 that may participate in the regulation, differentiation and function of thymus-dependent lymphocytes (T cells). A nomenclature for the family of polypeptides present in thymosin fraction 5 is suggested.

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Year:  1977        PMID： 265536      PMCID： PMC392366          DOI： 10.1073/pnas.74.2.725

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Purification and properties of bovine thymosin.

Authors:  J A Hooper; M C McDaniel; G B Thurman; G H Cohen; R S Schulof; A L Goldstein
Journal:  Ann N Y Acad Sci       Date:  1975-02-28       Impact factor: 5.691

2.  A new acid hydrolysis method for determining tryptophan in peptides and proteins.

Authors:  B Penke; R Ferenczi; K Kovács
Journal:  Anal Biochem       Date:  1974-07       Impact factor: 3.365

3.  Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from proteins.

Authors:  P Y Chou; G D Fasman
Journal:  Biochemistry       Date:  1974-01-15       Impact factor: 3.162

4.  Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone.

Authors:  J F Bach; M Dardenne; A L Goldstein; A Guha; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

5.  Isoelectric focusing in polyacrylamide gel and its application to immunoglobulins.

Authors:  Z L Awdeh; A R Williamson; B A Askonas
Journal:  Nature       Date:  1968-07-06       Impact factor: 49.962

6.  Purification and biological activity of thymosin, a hormone of the thymus gland.

Authors:  A L Goldstein; A Guha; M M Zatz; M A Hardy; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

7.  Use of fluorescamine in the chromatographic analysis of peptides from proteins.

Authors:  N Nakai; C Y Lai; B L Horecker
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

8.  The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells.

Authors:  D H Schlesinger; G Goldstein; H D Niall
Journal:  Biochemistry       Date:  1975-05-20       Impact factor: 3.162

9.  In vitro and in vivo studies with thymosin in cancer patients.

Authors:  L A Schafer; A L Goldstein; J U Gutterman; E M Hersh
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

10.  Thymosin corrects the abnormal DNA synthetic response of NZB mouse thymocytes.

Authors:  M J Dauphinee; N Talal; A L Goldstein; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205
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  60 in total

1.  Properties of the protein kinase that phosphorylates prothymosin alpha.

Authors:  A Peréz-Estévez; J Freire; C Sarandeses; G Covelo; C Díaz-Jullien; M Freire
Journal:  Mol Cell Biochem       Date:  2000-05       Impact factor: 3.396

2.  A pilot study of the safety and efficacy of thymosin alpha 1 in augmenting immune reconstitution in HIV-infected patients with low CD4 counts taking highly active antiretroviral therapy.

Authors:  D Chadwick; J Pido-Lopez; A Pires; N Imami; F Gotch; J S Villacian; S Ravindran; N I Paton
Journal:  Clin Exp Immunol       Date:  2003-12       Impact factor: 4.330

Review 3.  Hemopressin and other bioactive peptides from cytosolic proteins: are these non-classical neuropeptides?

Authors:  Julia S Gelman; Lloyd D Fricker
Journal:  AAPS J       Date:  2010-04-10       Impact factor: 4.009

Review 4.  Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date.

Authors:  E G Sandström; J C Kaplan
Journal:  Drugs       Date:  1987-09       Impact factor: 9.546

5.  Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ.

Authors:  M Clinton; L Graeve; H el-Dorry; E Rodriguez-Boulan; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

6.  A new monoclonal antibody to human subcapsular thymic epithelial cells.

Authors:  T Takeuchi; I Kubonishi; Y Ohtsuki; I Miyoshi
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1991

7.  Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action.

Authors:  C N Conteas; M G Mutchnick; K C Palmer; F E Weller; G D Luk; P H Naylor; M R Erdos; A L Goldstein; C Panneerselvam; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

8.  Generation of a monoclonal antibody against facteur thymique serique (FTS).

Authors:  K Ohga; G S Incefy; C Y Wang; R A Good
Journal:  Clin Exp Immunol       Date:  1982-03       Impact factor: 4.330

9.  Thymosins beta 8 and beta 9: two new peptides isolated from calf thymus homologous to thymosin beta 4.

Authors:  E Hannappel; S Davoust; B L Horecker
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

10.  Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays.

Authors:  Y Umeda; A Sakamoto; J Nakamura; H Ishitsuka; Y Yagi
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968
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