Literature DB >> 6314249

The complete nucleotide sequence of the gene coding for diphtheria toxin in the corynephage omega (tox+) genome.

G Ratti, R Rappuoli, G Giannini.   

Abstract

A segment of corynephage omega (tox+) DNA, containing the gene for diphtheria toxin (tox) was fragmented with restriction enzymes and the fragments cloned into M13 vectors for nucleotide sequence determination. A long open reading frame was shown to encode the tox gene by comparing the predicted amino acid sequence with that of peptides derived from the mature toxin molecule. Analysis of the nucleotide sequence shows RNA polymerase and ribosome binding signals preceding a GTG codon in the open reading frame: if this is the correct starting signal for translation, then a 25 amino acid signal peptide can be predicted for the toxin molecule.

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Year:  1983        PMID： 6314249      PMCID： PMC326401          DOI： 10.1093/nar/11.19.6589

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  19 in total

1.  Restriction map of corynebacteriophages beta c and beta vir and physical localization of the diphtheria tox operon.

Authors:  J J Costa; J L Michel; R Rappuoli; J R Murphy
Journal:  J Bacteriol       Date:  1981-10       Impact factor: 3.490

2.  A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides.

Authors:  D Perlman; H O Halvorson
Journal:  J Mol Biol       Date:  1983-06-25       Impact factor: 5.469

3.  Characterization of translational initiation sites in E. coli.

Authors:  G D Stormo; T D Schneider; L M Gold
Journal:  Nucleic Acids Res       Date:  1982-05-11       Impact factor: 16.971

4.  Use of the 'Perceptron' algorithm to distinguish translational initiation sites in E. coli.

Authors:  G D Stormo; T D Schneider; L Gold; A Ehrenfeucht
Journal:  Nucleic Acids Res       Date:  1982-05-11       Impact factor: 16.971

5.  Structure-activity relationships of the B fragment of diphtheria toxin: the lipid-binding domains.

Authors:  P Falmagne; C Capiau; J Zanen; G Kayser; J M Ruysschaert
Journal:  Toxicon       Date:  1982       Impact factor: 3.033

6.  Precursor in cotranslational secretion of diphtheria toxin.

Authors:  W P Smith; P C Tai; J R Murphy; B D Davis
Journal:  J Bacteriol       Date:  1980-01       Impact factor: 3.490

7.  The structure of two subgenomic RNAs from human influenza virus A/PR/8/34.

Authors:  G Winter; S Fields; G Ratti
Journal:  Nucleic Acids Res       Date:  1981-12-21       Impact factor: 16.971

8.  Evidence that the regulation of diphtheria toxin production is directed at the level of transcription.

Authors:  J R Murphy; J L Michel; M Teng
Journal:  J Bacteriol       Date:  1978-08       Impact factor: 3.490

9.  Restriction endonuclease map of the nontoxigenic corynephage gamma c and its relationship to the toxigenic corynephage beta c.

Authors:  J L Michel; R Rappuoli; J R Murphy; A M Pappenheimer
Journal:  J Virol       Date:  1982-05       Impact factor: 5.103
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  27 in total

1.  Retrospective diagnosis of diphtheria by detection of the Corynebacterium diphtheriae tox gene in a formaldehyde-fixed throat swab using PCR and sequencing analysis.

Authors:  T Komiya; N Shibata; M Ito; M Takahashi; Y Arakawa
Journal:  J Clin Microbiol       Date:  2000-06       Impact factor: 5.948

2.  Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

Authors:  J R Murphy; W Bishai; M Borowski; A Miyanohara; J Boyd; S Nagle
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

3.  Rapid screening for toxigenic Corynebacterium diphtheriae by the polymerase chain reaction.

Authors:  M J Pallen
Journal:  J Clin Pathol       Date:  1991-12       Impact factor: 3.411

4.  Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.

Authors:  M Pizza; A Bartoloni; A Prugnola; S Silvestri; R Rappuoli
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

5.  Similarity of the conformation of diphtheria toxin at high temperature to that in the membrane-penetrating low-pH state.

Authors:  J M Zhao; E London
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

6.  The nucleotide sequence of the gene coding for diphtheria toxoid CRM176.

Authors:  M Comanducci; S Ricci; R Rappuoli; G Ratti
Journal:  Nucleic Acids Res       Date:  1987-07-24       Impact factor: 16.971

7.  Functional expression of the genes of Escherichia coli in gram-positive Corynebacterium glutamicum.

Authors:  A Ozaki; R Katsumata; T Oka; A Furuya
Journal:  Mol Gen Genet       Date:  1984

8.  pH-dependence of the phospholipid interaction of diphtheria-toxin fragments.

Authors:  C Montecucco; G Schiavo; M Tomasi
Journal:  Biochem J       Date:  1985-10-01       Impact factor: 3.857

9.  NAD binding site of diphtheria toxin: identification of a residue within the nicotinamide subsite by photochemical modification with NAD.

Authors:  S F Carroll; R J Collier
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

10.  Characterization of the diphtheria tox transcript in Corynebacterium diphtheriae and Escherichia coli.

Authors:  D Leong; J R Murphy
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490
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