Literature DB >> 4062882

pH-dependence of the phospholipid interaction of diphtheria-toxin fragments.

C Montecucco, G Schiavo, M Tomasi.   

Abstract

Photoreactive phospholipids have been used to probe the lipid interaction of diphtheria toxin. Low pH values induce the membrane insertion of both the binding and enzymic fragments of the toxin. The efficiency of this process is much higher with asolectin than with egg lecithin (phosphatidylcholine)/cholesterol liposomes. The low-pH-induced interaction of the toxin fragments with the membrane hydrocarbon phase is more evident for the enzymic A-chain than for the binding B-chain, and it is fully reversed by returning the pH to neutrality.

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Year:  1985        PMID： 4062882      PMCID： PMC1152711          DOI： 10.1042/bj2310123

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  39 in total

1.  Structure and activity of diphtheria toxin. I. Thiol-dependent dissociation of a fraction of toxin into enzymically active and inactive fragments.

Authors:  R J Collier; J Kandel
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

2.  Interaction of diphtheria toxin fragments A, B and protein crm 45 with liposomes.

Authors:  P Boquet
Journal:  Eur J Biochem       Date:  1979-10-15

3.  Reconstitution of hybrid toxin from Fragment A of diphtheria toxin and a subunit of Wistaria floribunda lectin.

Authors:  T Uchida; M Yamaizumi; E Mekada; Y Okada; M Tsuda; T Kurokawa; Y Sugino
Journal:  J Biol Chem       Date:  1978-09-25       Impact factor: 5.157

4.  Interaction of the mitochondrial ATPase complex with phospholipids.

Authors:  C Montecucco; R Bisson; F Dabbeni-Sala; A Pitotti; H Gutweniger
Journal:  J Biol Chem       Date:  1980-11-10       Impact factor: 5.157

5.  N,N'-dicyclohexylcarbodiimide binds specifically to a single glutamyl residue of the proteolipid subunit of the mitochondrial adenosinetriphosphatases from Neurospora crassa and Saccharomyces cerevisiae.

Authors:  W Sebald; W Machleidt; E Wachter
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

6.  Interaction of membranous cytochrome b5 with arylazidophospholipids.

Authors:  R Bisson; C Montecucco; R A Capaldi
Journal:  FEBS Lett       Date:  1979-10-15       Impact factor: 4.124

7.  Preparation of a hybrid of fragment Fab' of antibody and fragment A of diphtheria toxin and its cytotoxicity.

Authors:  Y Masuho; T Hara; T Noguchi
Journal:  Biochem Biophys Res Commun       Date:  1979-09-12       Impact factor: 3.575

8.  The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin.

Authors:  D W Chung; R J Collier
Journal:  Biochim Biophys Acta       Date:  1977-08-11

9.  Binding of diphtheria toxin to phospholipids in liposomes.

Authors:  C R Alving; B H Iglewski; K A Urban; J Moss; R L Richards; J C Sadoff
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

10.  Dicyclohexylcarbodiimide binds specifically and covalently to cytochrome c oxidase while inhibiting its H+-translocating activity.

Authors:  R P Casey; M Thelen; A Azzi
Journal:  J Biol Chem       Date:  1980-05-10       Impact factor: 5.157
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  10 in total

1.  Cellular internalisation of bacterial toxins.

Authors:  M Thelestam
Journal:  Cytotechnology       Date:  1991-02       Impact factor: 2.058

2.  Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM(197), a mutant diphtheria toxin.

Authors:  E N Miyaji; R P Mazzantini; W O Dias; A L Nascimento; R Marcovistz; D S Matos; I Raw; N Winter; B Gicquel; R Rappuoli; L C Leite
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

3.  Effect of pH on the interaction of botulinum neurotoxins A, B and E with liposomes.

Authors:  C Montecucco; G Schiavo; B R Dasgupta
Journal:  Biochem J       Date:  1989-04-01       Impact factor: 3.857

4.  Refined structure of monomeric diphtheria toxin at 2.3 A resolution.

Authors:  M J Bennett; D Eisenberg
Journal:  Protein Sci       Date:  1994-09       Impact factor: 6.725

5.  The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms.

Authors:  Jie Wang; Erwin London
Journal:  Biochemistry       Date:  2009-11-03       Impact factor: 3.162

6.  Microsecond Simulations of the Diphtheria Toxin Translocation Domain in Association with Anionic Lipid Bilayers.

Authors:  Jose C Flores-Canales; Maria Kurnikova
Journal:  J Phys Chem B       Date:  2015-08-31       Impact factor: 2.991

7.  Topography of the TH5 Segment in the Diphtheria Toxin T-Domain Channel.

Authors:  Paul K Kienker; Zhengyan Wu; Alan Finkelstein
Journal:  J Membr Biol       Date:  2015-12-08       Impact factor: 1.843

8.  Dynamic properties of membrane proteins: reversible insertion into membrane vesicles of a colicin E1 channel-forming peptide.

Authors:  S Xu; W A Cramer; A A Peterson; M Hermodson; C Montecucco
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

9.  On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.

Authors:  E Papini; D Sandoná; R Rappuoli; C Montecucco
Journal:  EMBO J       Date:  1988-11       Impact factor: 11.598

10.  A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly.

Authors:  P Aullo; M Giry; S Olsnes; M R Popoff; C Kocks; P Boquet
Journal:  EMBO J       Date:  1993-03       Impact factor: 11.598
  10 in total

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