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Literature DB >> 6299279

Abundant amounts of diadenosine 5',5"'-P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human platelets.

Abstract

Diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) may be formed in the back reaction of the amino acid-activation reaction [Zamecnik, Stephenson, Janeway & Randerath (1966) Biochem. Biophys. Res. Commun. 24, 91-98]. On the basis of a number of observations of the properties of Ap4A it has been suggested that it may have a signal function for the initiation of DNA replication in eukaryotic cells] Grummt (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 371-375]. In the present paper human platelets have been shown to contain relatively large amounts of Ap4A. The compound is apparently metabolic inactive in platelets, but it is almost quantitatively released when platelets are activated to aggregate by treatment with thrombin. The results are discussed in connection with the known growth-stimulating activity of platelets.

Entities: Gene Species

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Year: 1982 PMID： 6299279 PMCID： PMC1154025 DOI： 10.1042/bj2080737

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

1. The performance of microparticle chemically-bonded anion-exchange resins in the analysis of nucleotides.

Authors: R A Hartwick; P R Brown
Journal: J Chromatogr Date: 1975-10-29

2. Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator".

Authors: E Rapaport; P C Zamecnik
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

3. Extraction procedures for use prior to HPLC nucleotide analysis using microparticle chemically bonded packings.

Authors: S C Chen; P R Brown; D M Rosie
Journal: J Chromatogr Sci Date: 1977-06 Impact factor: 1.618

4. Ribonucleoside and nucleotide components of normal human blood lymphocytes and platelets.

Authors: S H Pross; T W Klein; C W Fishel
Journal: Proc Soc Exp Biol Med Date: 1977-04

5. Determination of ATP and ADP in blood platelets: a modification of the firefly luciferase assay for plasma.

Authors: H Holmsen; E Storm; H J Day
Journal: Anal Biochem Date: 1972-04 Impact factor: 3.365

6. Isolation and characterization of dinucleoside tetra- and tri-phosphates formed in the presence of lysyl-sRNA synthetase.

Authors: K Randerath; C M Janeway; M L Stephenson; P C Zamecnik
Journal: Biochem Biophys Res Commun Date: 1966-07-06 Impact factor: 3.575

7. Priming of DNA synthesis by diadenosine 5',5"'-P1,P4-tetraphosphate with a double-stranded octadecamer as a template and DNA polymerase alpha.

Authors: P C Zamecnik; E Rapaport; E F Baril
Journal: Proc Natl Acad Sci U S A Date: 1982-03 Impact factor: 11.205

8. Adenine nucleotide metabolism of blood platelets. VI. Subcellular localization of nucleotide pools with different functions in the platelet release reaction.

Authors: H Holmsen; H J Day; E Storm
Journal: Biochim Biophys Acta Date: 1969-08-20

9. Characterization of human platelet vascular permeability-enhancing activity.

Authors: R L Nachman; B Weksler; B Ferris
Journal: J Clin Invest Date: 1972-03 Impact factor: 14.808

10. Thermodynamic parameters for the hydrolysis of inorganic pyrophosphate at pH 7.4 as a function of (Mg2+), (K+), and ionic strength determined from equilibrium studies of the reaction.

Authors: H Flodgaard; P Fleron
Journal: J Biol Chem Date: 1974-06-10 Impact factor: 5.157

38 in total

1. Ca(2+)-stores mobilization by diadenosine tetraphosphate, Ap4A, through a putative P2Y purinoceptor in adrenal chromaffin cells.

Authors: E Castro; J Pintor; M T Miras-Portugal
Journal: Br J Pharmacol Date: 1992-08 Impact factor: 8.739

2. Antithrombotic effect of beta,beta'-monochloromethylene diadenosine 5',5"'-P1,P4-tetraphosphate.

Authors: B K Kim; P Zamecnik; G Taylor; M J Guo; G M Blackburn
Journal: Proc Natl Acad Sci U S A Date: 1992-11-15 Impact factor: 11.205

Review 3. Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system.

Authors: Vera Jankowski; Markus van der Giet; Harald Mischak; Michael Morgan; Walter Zidek; Joachim Jankowski
Journal: Br J Pharmacol Date: 2009-06-25 Impact factor: 8.739

4. Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.

Authors: G M Blackburn; X Liu; A Rösler; C Brenner
Journal: Nucleosides Nucleotides Date: 1998 Jan-Mar

5. Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein.

Authors: L Gasmi; A G McLennan; S W Edwards
Journal: Immunology Date: 1997-01 Impact factor: 7.397

10. Acyl coenzyme A synthetase from Pseudomonas fragi catalyzes the synthesis of adenosine 5'-polyphosphates and dinucleoside polyphosphates.

Authors: R Fontes; M A Sillero; A Sillero
Journal: J Bacteriol Date: 1998-06 Impact factor: 3.490