Literature DB >> 19563527

Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system.

Vera Jankowski1, Markus van der Giet, Harald Mischak, Michael Morgan, Walter Zidek, Joachim Jankowski.   

Abstract

The purinergic system is composed of mononucleosides, mononucleoside polyphosphates and dinucleoside polyphosphates as agonists, as well as the respective purinergic receptors. Interest in the role of the purinergic system in cardiovascular physiology and pathophysiology is on the rise. This review focuses on the overall impact of dinucleoside polyphosphates in the purinergic system. Platelets, adrenal glands, endothelial cells, cardiomyocytes and tubular cells release dinucleoside polyphosphates. Plasma concentrations of dinucleoside polyphosphates are sufficient to cause direct vasoregulatory effects and to induce proliferative effects on vascular smooth muscle cells and mesangial cells. In addition, increased plasma concentrations of a dinucleoside polyphosphate were recently demonstrated in juvenile hypertensive patients. In conclusion, the current literature accentuates the strong physiological and pathophysiological impact of dinucleoside polyphosphates on the cardiovascular system.

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Year:  2009        PMID： 19563527      PMCID： PMC2743832          DOI： 10.1111/j.1476-5381.2009.00337.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  157 in total

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Authors:  C Chen; M S Parker; A P Barnes; P Deininger; R P Bobbin
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Review 2.  Synaptic P2X receptors.

Authors:  S J Robertson; S J Ennion; R J Evans; F A Edwards
Journal:  Curr Opin Neurobiol       Date:  2001-06       Impact factor: 6.627

Review 3.  Regulation of platelet functions by P2 receptors.

Authors:  Christian Gachet
Journal:  Annu Rev Pharmacol Toxicol       Date:  2006       Impact factor: 13.820

4.  Ecto-enzymatic hydrolysis of diadenosine polyphosphates by cultured adrenomedullary vascular endothelial cells.

Authors:  J Mateo; M T Miras-Portugal; P Rotllán
Journal:  Am J Physiol       Date:  1997-09

5.  Differential regulation of phospholipase A2 (PLA2)-dependent Ca2+ signaling in smooth muscle by cAMP- and cGMP-dependent protein kinases. Inhibitory phosphorylation of PLA2 by cyclic nucleotide-dependent protein kinases.

Authors:  K S Murthy; G M Makhlouf
Journal:  J Biol Chem       Date:  1998-12-18       Impact factor: 5.157

Review 6.  Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways.

Authors:  Esmerilda G Delicado; M Teresa Miras-Portugal; Luz María G Carrasquero; David León; Raquel Pérez-Sen; Javier Gualix
Journal:  Pflugers Arch       Date:  2006-05-11       Impact factor: 3.657

7.  P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels.

Authors:  A Nicke; H G Bäumert; J Rettinger; A Eichele; G Lambrecht; E Mutschler; G Schmalzing
Journal:  EMBO J       Date:  1998-06-01       Impact factor: 11.598

8.  Endogenous ATP released by electrical field stimulation causes contraction via P2x- and P2y-purinoceptors in the isolated tail artery of rats.

Authors:  A Fukumitsu; Y Takano; A Iki; K Honda; R Saito; T Katsuragi; H Kamiya
Journal:  Jpn J Pharmacol       Date:  1999-12

Review 9.  Control of epithelial transport via luminal P2 receptors.

Authors:  Jens Leipziger
Journal:  Am J Physiol Renal Physiol       Date:  2003-03

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Authors:  L C Rump; V Oberhauser; I von Kügelgen
Journal:  Kidney Int       Date:  1998-08       Impact factor: 10.612
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  23 in total

Review 1.  Medicinal chemistry of adenosine, P2Y and P2X receptors.

Authors:  Kenneth A Jacobson; Christa E Müller
Journal:  Neuropharmacology       Date:  2015-12-12       Impact factor: 5.250

Review 2.  Nucleotides Acting at P2Y Receptors: Connecting Structure and Function.

Authors:  Kenneth A Jacobson; Silvia Paoletta; Vsevolod Katritch; Beili Wu; Zhan-Guo Gao; Qiang Zhao; Raymond C Stevens; Evgeny Kiselev
Journal:  Mol Pharmacol       Date:  2015-04-02       Impact factor: 4.436

3.  The endothelium-derived contracting factor uridine adenosine tetraphosphate induces P2Y(2)-mediated pro-inflammatory signaling by monocyte chemoattractant protein-1 formation.

Authors:  Mirjam Schuchardt; Jasmin Prüfer; Nicole Prüfer; Annette Wiedon; Tao Huang; Miriam Chebli; Vera Jankowski; Joachim Jankowski; Monika Schäfer-Korting; Walter Zidek; Markus van der Giet; Markus Tölle
Journal:  J Mol Med (Berl)       Date:  2011-04-13       Impact factor: 4.599

Review 4.  Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update.

Authors:  Zhichao Zhou; Takayuki Matsumoto; Vera Jankowski; John Pernow; S Jamal Mustafa; Dirk J Duncker; Daphne Merkus
Journal:  Pharmacol Res       Date:  2018-12-13       Impact factor: 7.658

5.  Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.

Authors:  Shir Yelovitch; Jean Camden; Gary A Weisman; Bilha Fischer
Journal:  J Med Chem       Date:  2011-12-07       Impact factor: 7.446

6.  The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates.

Authors:  David Fernández-Justel; Rafael Peláez; José Luis Revuelta; Rubén M Buey
Journal:  J Biol Chem       Date:  2019-08-15       Impact factor: 5.157

7.  Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats.

Authors:  Takayuki Matsumoto; Rita C Tostes; R Clinton Webb
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-05-06       Impact factor: 4.733

8.  Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney.

Authors:  Markus Tölle; Mirjam Schuchardt; Annette Wiedon; Tao Huang; Lars Klöckel; Joachim Jankowski; Vera Jankowski; Walter Zidek; Markus van der Giet
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

9.  The enzymatic activity of the VEGFR2 receptor for the biosynthesis of dinucleoside polyphosphates.

Authors:  Vera Jankowski; Anna Schulz; Axel Kretschmer; Harald Mischak; Falko Boehringer; Markus van der Giet; Doreen Janke; Mirjam Schuchardt; Ralf Herwig; Walter Zidek; Joachim Jankowski
Journal:  J Mol Med (Berl)       Date:  2013-05-01       Impact factor: 4.599

10.  Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors.

Authors:  Javier Gualix; Rosa Gómez-Villafuertes; Jesús Pintor; Marta Llansola; Vicente Felipo; M Teresa Miras-Portugal
Journal:  Purinergic Signal       Date:  2013-08-13       Impact factor: 3.765
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