Literature DB >> 9708352

Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.

G M Blackburn1, X Liu, A Rösler, C Brenner.   

Abstract

The design and synthesis of analogues of diadenosine 5',5"'-P1,P3-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.

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Year:  1998        PMID： 9708352      PMCID： PMC2556045          DOI： 10.1080/07328319808005178

Source DB:  PubMed          Journal:  Nucleosides Nucleotides        ISSN： 0732-8311


  14 in total

1.  Antithrombotic effect of beta,beta'-monochloromethylene diadenosine 5',5"'-P1,P4-tetraphosphate.

Authors:  B K Kim; P Zamecnik; G Taylor; M J Guo; G M Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

2.  The occurrence of P1, P4-diguanosine 5'-tetraphosphate in brine shrimp eggs.

Authors:  F J FINAMORE; A H WARNER
Journal:  J Biol Chem       Date:  1963-01       Impact factor: 5.157

3.  Structure and expression of the human FHIT gene in normal and tumor cells.

Authors:  T Druck; P Hadaczek; T B Fu; M Ohta; Z Siprashvili; R Baffa; M Negrini; K Kastury; M L Veronese; D Rosen; J Rothstein; P McCue; M G Cotticelli; H Inoue; C M Croce; K Huebner
Journal:  Cancer Res       Date:  1997-02-01       Impact factor: 12.701

4.  Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate.

Authors:  G M Blackburn; G E Taylor; G R Thatcher; M Prescott; A G McLennan
Journal:  Nucleic Acids Res       Date:  1987-09-11       Impact factor: 16.971

5.  Abundant amounts of diadenosine 5',5"'-P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human platelets.

Authors:  H Flodgaard; H Klenow
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

6.  Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) asymmetrical hydrolase: sequence similarity with the histidine triad (HIT) protein family.

Authors:  Y Huang; P N Garrison; L D Barnes
Journal:  Biochem J       Date:  1995-12-15       Impact factor: 3.857

7.  Regiospecificity of the hydrolysis of diadenosine polyphosphates catalyzed by three specific pyrophosphohydrolases.

Authors:  A Guranowski; P Brown; P A Ashton; G M Blackburn
Journal:  Biochemistry       Date:  1994-01-11       Impact factor: 3.162

8.  The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

Authors:  M Ohta; H Inoue; M G Cotticelli; K Kastury; R Baffa; J Palazzo; Z Siprashvili; M Mori; P McCue; T Druck; C M Croce; K Huebner
Journal:  Cell       Date:  1996-02-23       Impact factor: 41.582

9.  The presence of diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) in human platelets.

Authors:  J Lüthje; A Ogilvie
Journal:  Biochem Biophys Res Commun       Date:  1983-08-30       Impact factor: 3.575

10.  Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.

Authors:  L D Barnes; P N Garrison; Z Siprashvili; A Guranowski; A K Robinson; S W Ingram; C M Croce; M Ohta; K Huebner
Journal:  Biochemistry       Date:  1996-09-10       Impact factor: 3.162
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  8 in total

1.  Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.

Authors:  Charles Brenner
Journal:  Biochemistry       Date:  2002-07-23       Impact factor: 3.162

2.  Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.

Authors:  H C Pace; P N Garrison; A K Robinson; L D Barnes; A Draganescu; A Rösler; G M Blackburn; Z Siprashvili; C M Croce; K Huebner; C Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-12       Impact factor: 11.205

Review 3.  The histidine triad superfamily of nucleotide-binding proteins.

Authors:  C Brenner; P Bieganowski; H C Pace; K Huebner
Journal:  J Cell Physiol       Date:  1999-11       Impact factor: 6.384

4.  Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates.

Authors:  A Draganescu; S C Hodawadekar; K R Gee; C Brenner
Journal:  J Biol Chem       Date:  2000-02-18       Impact factor: 5.157

5.  Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.

Authors:  C Brenner; H C Pace; P N Garrison; A K Robinson; A Rosler; X H Liu; G M Blackburn; C M Croce; K Huebner; L D Barnes
Journal:  Protein Eng       Date:  1997-12

6.  Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.

Authors:  Malwina Strenkowska; Joanna Kowalska; Maciej Lukaszewicz; Joanna Zuberek; Wei Su; Robert E Rhoads; Edward Darzynkiewicz; Jacek Jemielity
Journal:  New J Chem       Date:  2010-01-01       Impact factor: 3.591

7.  Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.

Authors:  Francesco Trapasso; Agnieszka Krakowiak; Rossano Cesari; Jeffrey Arkles; Sai Yendamuri; Hideshi Ishii; Andrea Vecchione; Tamotsu Kuroki; Pawel Bieganowski; Helen C Pace; Kay Huebner; Carlo M Croce; Charles Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-06       Impact factor: 11.205

8.  Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement.

Authors:  James M Varnum; Janina Baraniak; Renata Kaczmarek; Wojciech J Stec; Charles Brenner
Journal:  BMC Chem Biol       Date:  2001
  8 in total

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