Literature DB >> 6164047

Evidence for a unique human fibroblast interferon (IFN-beta 1) chromosomal gene, devoid of intervening sequences.

J Tavernier, R Derynck, W Fiers.   

Abstract

Direct restriction analysis of the human genome, using the Southern transfer technique and hybridization with a human fibroblast interferon (IFN-beta) complementary DNA insert probe, revealed the presence of a single gene; no additional closely related IFN-beta genes could be detected. A lambda-linked human gene library (Lawn et al., Cell, 15, 1157-1174 (1978)) was screened using the cDNA probe. Out of 600,000 recombinant phage examined, one single clone bearing interferon sequences was obtained. Restriction analysis of the relevant region revealed an identical restriction map as obtained for the IFN-beta 1 cDNA clones. No intervening sequences could be detected, either in the coding or the non-coding regions of the gene.

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Year:  1981        PMID： 6164047      PMCID： PMC327215          DOI： 10.1093/nar/9.3.461

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  34 in total

1.  Heterogeneity of poly(I) x poly(C)-induced human fibroblast interferon mRNA species.

Authors:  P B Sehgal; A D Sagar
Journal:  Nature       Date:  1980-11-06       Impact factor: 49.962

2.  Synthesis of human fibroblast interferon by E. coli.

Authors:  D V Goeddel; H M Shepard; E Yelverton; D Leung; R Crea; A Sloma; S Pestka
Journal:  Nucleic Acids Res       Date:  1980-09-25       Impact factor: 16.971

3.  The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

Authors:  S Nagata; N Mantei; C Weissmann
Journal:  Nature       Date:  1980-10-02       Impact factor: 49.962

4.  A family of structural genes for human lymphoblastoid (leukocyte-type) interferon.

Authors:  G Allen; K H Fantes
Journal:  Nature       Date:  1980-10-02       Impact factor: 49.962

5.  The nucleotide sequence of human fibroblast interferon cDNA.

Authors:  T Taniguchi; S Ohno; Y Fujii-Kuriyama; M Muramatsu
Journal:  Gene       Date:  1980-06       Impact factor: 3.688

6.  Plasmid screening at high colony density.

Authors:  D Hanahan; M Meselson
Journal:  Gene       Date:  1980-06       Impact factor: 3.688

7.  At least three human type alpha interferons: structure of alpha 2.

Authors:  M Streuli; S Nagata; C Weissmann
Journal:  Science       Date:  1980-09-19       Impact factor: 47.728

8.  Human leukocyte interferon produced by E. coli is biologically active.

Authors:  D V Goeddel; E Yelverton; A Ullrich; H L Heyneker; G Miozzari; W Holmes; P H Seeburg; T Dull; L May; N Stebbing; R Crea; S Maeda; R McCandliss; A Sloma; J M Tabor; M Gross; P C Familletti; S Pestka
Journal:  Nature       Date:  1980-10-02       Impact factor: 49.962

9.  The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase.

Authors:  M Houghton; M A Easton; A G Stewart; J C Smith; S M Doel; G H Catlin; H M Lewis; T P Patel; J S Emtage; N H Carey; A G Porter
Journal:  Nucleic Acids Res       Date:  1980-07-11       Impact factor: 16.971

10.  Human leukocyte and fibroblast interferons are structurally related.

Authors:  T Taniguchi; N Mantei; M Schwarzstein; S Nagata; M Muramatsu; C Weissmann
Journal:  Nature       Date:  1980-06-19       Impact factor: 49.962
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  26 in total

1.  The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression.

Authors:  Vivian Ruvolo; Lorena Navarro; Clare E Sample; Michael David; Seung Sung; Sankar Swaminathan
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

2.  Zygosity determination in newborn twins using DNA variants.

Authors:  C Derom; E Bakker; R Vlietinck; R Derom; H Van den Berghe; M Thiery; P Pearson
Journal:  J Med Genet       Date:  1985-08       Impact factor: 6.318

3.  Switch recombination in normal IgA1+ B lymphocytes.

Authors:  J Irsch; S Irlenbusch; J Radl; P D Burrows; M D Cooper; A H Radbruch
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

4.  Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.

Authors:  N B Raj; P M Pitha
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

5.  Differential expression of human interferon genes.

Authors:  J Hiscott; K Cantell; C Weissmann
Journal:  Nucleic Acids Res       Date:  1984-05-11       Impact factor: 16.971

6.  Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells.

Authors:  K Zinn; P Mellon; M Ptashne; T Maniatis
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

7.  Regulated expression of human interferon beta 1 gene after transduction into cultured mouse and rabbit cells.

Authors:  D Canaani; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

8.  Genomic footprinting: detection of putative regulatory proteins in the promoter region of the interferon alpha-1 gene in normal human tissues.

Authors:  M Palmieri; M G Tovey
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

9.  Human fibroblast interferon RNA transcripts of different sizes in poly(I).poly(C) induced cells.

Authors:  J Content; L De Wit; J Tavernier; W Fiers
Journal:  Nucleic Acids Res       Date:  1983-05-11       Impact factor: 16.971

10.  The structure of a thirty-six kilobase region of the human chromosome including the fibroblast interferon gene IFN-beta.

Authors:  G Gross; U Mayr; W Bruns; F Grosveld; H M Dahl; J Collins
Journal:  Nucleic Acids Res       Date:  1981-06-11       Impact factor: 16.971
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