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Literature DB >> 6033768

The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver.

Abstract

A comparison has been made of the difference spectra obtained by causing various aflatoxins (B(1), G(1) and G(2)) to interact with calf-thymus DNA. The effect of these toxins on RNA and protein synthesis by rat-liver slices has been measured. The extent of their inhibitory action on the synthetic reactions was proportional to the degree of spectral shift obtained with their interaction with DNA. It is proposed that their toxicity depends on this interaction. It was demonstrated that the RNA polymerase of nucleoli isolated from the livers of aflatoxin B(1)-poisoned rats was inhibited. This finding is in agreement with the proposed mechanism for the hepatotoxic action of aflatoxin.

Entities: Chemical Disease Gene Species

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Year: 1967 PMID： 6033768 PMCID： PMC1270395 DOI： 10.1042/bj1030258

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

11 in total

1. AFLATOXIN G1: DIRECT DETERMINATION OF THE STRUCTURE BY THE METHOD OF ISOMORPHOUS REPLACEMENT.

Authors: K K CHEUNG; G A SIM
Journal: Nature Date: 1964-03-21 Impact factor: 49.962

2. AFLATOXIN B2: CHEMICAL IDENTITY AND BIOLOGICAL ACTIVITY.

Authors: S B CHANG; M M ABDEL-KADER; E L WICK; G N WOGAN
Journal: Science Date: 1963-11-29 Impact factor: 47.728

3. EFFECTS OF THIOACETAMIDE ON LABELING OF RIBONUCLEIC ACID OF ISOLATED NUCLEOLI IN VITRO.

Authors: J G VILLALOBOS; W J STEELE; H BUSCH
Journal: Biochim Biophys Acta Date: 1964-10-16

4. The metabolism of isolated rat-liver nucleoli and other subnuclear fractions. The active site of amino acid incorporation in the nucleus.

Authors: K R REES; G F ROWLAND; J S VARCOE
Journal: Biochem J Date: 1963-01 Impact factor: 3.857

5. The metabolism of isolated rat-liver nuclei.

Authors: K R REES; G F ROWLAND
Journal: Biochem J Date: 1961-01 Impact factor: 3.857

6. Aspergillus flavus and turkey X disease. Toxic metabolites of Aspergillus flavus.

Authors: B F NESBITT; J O'KELLY; K SARGEANT; A SHERIDAN
Journal: Nature Date: 1962-09-15 Impact factor: 49.962

7. Aflatoxin: a site of action in the rat liver cell.

Authors: J I Clifford; K R Rees
Journal: Nature Date: 1966-01-15 Impact factor: 49.962

8. Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Authors: M B Sporn; C W Dingman; H L Phelps; G N Wogan
Journal: Science Date: 1966-03-25 Impact factor: 47.728

9. The action of aflatoxin B1 on the rat liver.

Authors: J I Clifford; K R Rees
Journal: Biochem J Date: 1967-01 Impact factor: 3.857

10. Further studies on the carcinogenic and growth-inhibitory activity of lactones and related substances.

Authors: F DICKENS; H E JONES
Journal: Br J Cancer Date: 1963-03 Impact factor: 7.640

12 in total

Review 1. Biological activities of mycotoxins.

Authors: A W Hayes
Journal: Mycopathologia Date: 1978-12-18 Impact factor: 2.574

2. The distribution of tritium-labeled aflatoxin B1, dihydro-aflatoxin B1, and tetrahydrodesoxoaflatoxin B1 in liver cells cultured in vitro from the chicken embryo.

Authors: K Terao; M Yamazaki; K Miyaki
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1972-12-29

The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver.

1. AFLATOXIN G1: DIRECT DETERMINATION OF THE STRUCTURE BY THE METHOD OF ISOMORPHOUS REPLACEMENT.

2. AFLATOXIN B2: CHEMICAL IDENTITY AND BIOLOGICAL ACTIVITY.

3. EFFECTS OF THIOACETAMIDE ON LABELING OF RIBONUCLEIC ACID OF ISOLATED NUCLEOLI IN VITRO.

4. The metabolism of isolated rat-liver nucleoli and other subnuclear fractions. The active site of amino acid incorporation in the nucleus.

5. The metabolism of isolated rat-liver nuclei.

6. Aspergillus flavus and turkey X disease. Toxic metabolites of Aspergillus flavus.

7. Aflatoxin: a site of action in the rat liver cell.

8. Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

9. The action of aflatoxin B1 on the rat liver.

10. Further studies on the carcinogenic and growth-inhibitory activity of lactones and related substances.

Review 1. Biological activities of mycotoxins.

2. The distribution of tritium-labeled aflatoxin B1, dihydro-aflatoxin B1, and tetrahydrodesoxoaflatoxin B1 in liver cells cultured in vitro from the chicken embryo.

3. Different susceptibilities of chick embryo liver cells in vitro to aflatoxin, actinomycin D, and mitomycin C.

4. [Significance of the aflatoxins].

5. Further studies on the toxicity of the aflatoxins on human cell cultures.

6. Mutagenic activities of aflatoxin B 1 and G 1 in Neurospora crassa.

7. Interaction between aflatoxin B1 and oxytetracycline in isolated rat hepatocytes.

8. A comparative study of the effect of aflatoxin B and actinomycin D on HeLa cells.

9. The interaction of aflatoxin B1 with polynucleotides and its effect on ribonucleic acid polymerase.

10. The interaction of aflatoxins with purines and purine nucleosides.