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Literature DB >> 4897460

A comparative study of the effect of aflatoxin B and actinomycin D on HeLa cells.

Abstract

1. The cytotoxic effects of aflatoxin B(1) on HeLa cells were examined and effects of short exposures of the cells to the toxin were found to be reversible. 2. Aflatoxin B(1) inhibited the synthesis of both ribosomal and heterodisperse RNA. It is proposed that the toxin's mechanism of action on ribosomal RNA synthesis is related to its inhibitory effect on the maturation of the 45s-ribosomal-RNA precursor. 3. Protein synthesis is inhibited to a greater extent by aflatoxin B(1) than by actinomycin D. In contrast with actinomycin D, aflatoxin B(1) was shown to disaggregate polyribosomes directly.

Entities: Chemical

Mesh：

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Year: 1969 PMID： 4897460 PMCID： PMC1184854 DOI： 10.1042/bj1140289

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

31 in total

1. CARCINOGENIC ACTIVITY OF AFLATOXIN TO RATS.

Authors: J BARNES; W H BUTLER
Journal: Nature Date: 1964-06-06 Impact factor: 49.962

2. Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells.

Authors: K SCHERRER; H LATHAM; J E DARNELL
Journal: Proc Natl Acad Sci U S A Date: 1963-02-15 Impact factor: 11.205

3. POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA.

Authors: S Penman; K Scherrer; Y Becker; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1963-05 Impact factor: 11.205

4. Inhibition of protein and RNA synthesis in HeLa cells by levallorphan and levorphanol.

Authors: W D Noteboom; G C Mueller
Journal: Mol Pharmacol Date: 1966-11 Impact factor: 4.436

5. Specific nuclear and nucleolar ultrastructural lesions induced by proflavin and similarly acting antimetabolites in tissue culture.

Authors: R Simard
Journal: Cancer Res Date: 1966-11 Impact factor: 12.701

6. Induction of chromosome aberrations by aflatoxin.

Authors: L J Lilly
Journal: Nature Date: 1965-07-24 Impact factor: 49.962

7. Methylation of 45 s ribosomal RNA precursor in HeLa cells.

Authors: E F Zimmerman; B W Holler
Journal: J Mol Biol Date: 1967-01-28 Impact factor: 5.469

8. Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA.

Authors: J R Warner; R Soeiro; H C Birnboim; M Girard; J E Darnell
Journal: J Mol Biol Date: 1966-08 Impact factor: 5.469

9. Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Authors: M B Sporn; C W Dingman; H L Phelps; G N Wogan
Journal: Science Date: 1966-03-25 Impact factor: 47.728

10. Oral, subcutaneous and intratracheal administration of carcinogenic lactones and related substances: the intratracheal administration of cigarette tar in the rat.

Authors: F Dickens; H E Jones; H B Waynforth
Journal: Br J Cancer Date: 1966-03 Impact factor: 7.640

7 in total

A comparative study of the effect of aflatoxin B and actinomycin D on HeLa cells.

1. CARCINOGENIC ACTIVITY OF AFLATOXIN TO RATS.

2. Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells.

3. POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA.

4. Inhibition of protein and RNA synthesis in HeLa cells by levallorphan and levorphanol.

5. Specific nuclear and nucleolar ultrastructural lesions induced by proflavin and similarly acting antimetabolites in tissue culture.

6. Induction of chromosome aberrations by aflatoxin.

7. Methylation of 45 s ribosomal RNA precursor in HeLa cells.

8. Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA.

9. Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

10. Oral, subcutaneous and intratracheal administration of carcinogenic lactones and related substances: the intratracheal administration of cigarette tar in the rat.

1. A diploid rat liver cell culture. 2. Effect of aflatoxin B1 on ribonucleic acid synthesis.

2. Growth and aflatoxin production by Aspergillus parasiticus when in the presence of Streptococcus lactis.

3. A diploid rat liver cell culture. 1. Characterization and sensitivity to aflatoxin B1.

4. Response of culture human skin fibroblasts to aflatoxin B1.

5. Interaction between Streptococcus lactis and Aspergillus flavus on production of aflatoxin.

6. Tropical cirrhosis and hepatoma.

7. The effects of aflatoxin B 1 in vivo on membrane--ribosome association.