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Literature DB >> 5909585

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

M B Sporn, C W Dingman, H L Phelps, G N Wogan.

Abstract

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.

Entities: Chemical Disease Species

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Year: 1966 PMID： 5909585 DOI： 10.1126/science.151.3717.1539

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

33 in total

Review 1. Metabolism of a prototype mycotoxin, aflatoxin B1, and its genetic regulation.

Authors: H L Gurtoo; R Dahms; J B Vaught
Journal: Mycopathologia Date: 1978-12-18 Impact factor: 2.574

2. Effects of Phosfon-S on Nucleic Acid Metabolism in Pisum sativum Alaska.

Authors: J Brook; S H West; D S Anthony
Journal: Plant Physiol Date: 1967-06 Impact factor: 8.340

3. Production of Aflatoxins by Aspergillus flavus Cultured on Flue-Cured Tobacco.

Authors: H E Pattee
Journal: Appl Microbiol Date: 1969-11

4. Genetic regulatory mechanisms and carcinogenesis.

Authors: H V Gelboin; R Bates
Journal: Public Health Rep Date: 1966-09 Impact factor: 2.792

5. Subcellular alterations produced by the carcinogen, aflatoxin B1 in tentacle epithelium of the mollusk, Physa fontinales L.

Authors: L Bauer; A H Tulusan
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1973-05-07

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Review 1. Metabolism of a prototype mycotoxin, aflatoxin B1, and its genetic regulation.

2. Effects of Phosfon-S on Nucleic Acid Metabolism in Pisum sativum Alaska.

3. Production of Aflatoxins by Aspergillus flavus Cultured on Flue-Cured Tobacco.

4. Genetic regulatory mechanisms and carcinogenesis.

5. Subcellular alterations produced by the carcinogen, aflatoxin B1 in tentacle epithelium of the mollusk, Physa fontinales L.

6. Different susceptibilities of chick embryo liver cells in vitro to aflatoxin, actinomycin D, and mitomycin C.

7. Effect of aflatoxin B1 on a deoxyribonucleic acid-dependent ribonucleic acid polymerase in vitro.

8. The effect of aflatoxin B 1 on normal and cortisol-stimulated rat liver ribonucleic acid synthesis.

9. A comparative study of the effect of aflatoxin B and actinomycin D on HeLa cells.

10. The interaction of aflatoxin B1 with polynucleotides and its effect on ribonucleic acid polymerase.