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Literature DB >> 6032981

The interaction of aflatoxins with purines and purine nucleosides.

Abstract

From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino group play a role in the binding of all the aflatoxins to DNA.

Entities: Chemical

Mesh：

Substances：

Year: 1967 PMID： 6032981 PMCID： PMC1270429 DOI： 10.1042/bj1030467

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

9 in total

1. ANTIMETABOLITES AFFECTING PROTEIN OR NUCLEIC ACID SYNTHESIS. PHLEOMYCIN, AN INHIBITOR OF DNA POLYMERASE.

Authors: A FALASCHI; A KORNBERG
Journal: Fed Proc Date: 1964 Sep-Oct

2. ACTINOMYCIN D. EFFECTS ON NUCLEIC ACID AND PROTEIN METABOLISM IN INTACT AND REGENERATING LIVER OF RATS.

Authors: H S SCHWARTZ; J E SODERGREN; M GAROFALO; S S STERNBERG
Journal: Cancer Res Date: 1965-04 Impact factor: 12.701

3. On the factors controlling the reversibility of DNA denaturation.

Authors: E P GEIDUSCHEK
Journal: J Mol Biol Date: 1962-06 Impact factor: 5.469

4. Interaction of actinomycin C with constituents of nucleic acids.

Authors: W KERSTEN
Journal: Biochim Biophys Acta Date: 1961-03-04

5. [Early nucleolar lesions induced by aflatoxin in rat hepatic cells].

Authors: W Bernhard; C Frayssinet; C Lafarge; E Le Breton
Journal: C R Acad Hebd Seances Acad Sci D Date: 1965-08-18

6. Aflatoxin: a site of action in the rat liver cell.

Authors: J I Clifford; K R Rees
Journal: Nature Date: 1966-01-15 Impact factor: 49.962

7. [Action of aflatoxin on DNA metabolism during compensatory hypertrophy of the liver after partial hepatectomy].

Authors: A M de Recondo; C Frayssinet; C Lafarge; E Le Breton
Journal: Biochim Biophys Acta Date: 1966-05-19

8. Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Authors: M B Sporn; C W Dingman; H L Phelps; G N Wogan
Journal: Science Date: 1966-03-25 Impact factor: 47.728

9. The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver.

Authors: J I Clifford; K R Rees; M E Stevens
Journal: Biochem J Date: 1967-04 Impact factor: 3.857

9 in total

12 in total

1. The effect of heliotrine, a pyrrolizidine alkaloid, on human liver cells in culture.

Authors: S F Sullman; A J Zuckerman
Journal: Br J Exp Pathol Date: 1969-08

2. Effect of aflatoxin B1 on chromatin-bound ribonucleic acid polymerase and nucleic acid and protein synthesis in germinating maize seeds.

Authors: R K Tripathi; R S Misra
Journal: Appl Environ Microbiol Date: 1981-09 Impact factor: 4.792

3. The effect of aflatoxin B 1 on normal and cortisol-stimulated rat liver ribonucleic acid synthesis.

Authors: G E Neal
Journal: Biochem J Date: 1972-11 Impact factor: 3.857

4. The interaction of aflatoxin B1 with polynucleotides and its effect on ribonucleic acid polymerase.

Authors: A M King; B H Nicholson
Journal: Biochem J Date: 1969-10 Impact factor: 3.857

5. Uptake, distribution and binding of beryllium to organelles of the rat liver cell.

Authors: H P Witschi; W N Aldridge
Journal: Biochem J Date: 1968-02 Impact factor: 3.857

6. The effects of aflatoxin B1 and palmotoxins B0 and G0 on the germination and leaf colour of the cowpea (Vigna sinensis).

Authors: A A Adekunle; O Bassir
Journal: Mycopathol Mycol Appl Date: 1973-12-15