Literature DB >> 485133

Inhibition by ethambutol of mycolic acid transfer into the cell wall of Mycobacterium smegmatis.

K Takayama, E L Armstrong, K A Kunugi, J O Kilburn.   

Abstract

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of Mycobacterium smegmatis. Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive inhibition was involved.

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Year:  1979        PMID： 485133      PMCID： PMC352831          DOI： 10.1128/AAC.16.2.240

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  A new synthetic compound with antituberculous activity in mice: ethambutol (dextro-2,2'-(ethylenediimino)-di-l-butanol).

Authors:  J P THOMAS; C O BAUGHN; R G WILKINSON; R G SHEPHERD
Journal:  Am Rev Respir Dis       Date:  1961-06

2.  Clinical experience with ethambutol.

Authors:  T M Wilson
Journal:  Antibiot Chemother       Date:  1970

3.  Metabolic role of free mycolic acids in Mycobacterium tuberculosis.

Authors:  K Takayama; E L Armstrong
Journal:  J Bacteriol       Date:  1977-04       Impact factor: 3.490

Review 4.  Myambutol: chemistry, pharmacology, and toxicology.

Authors:  R Kanther
Journal:  Antibiot Chemother       Date:  1970

5.  Effects of ethionamide and isoxyl on mycolic acid synthesis in Mycobacterium tuberculosis BCG.

Authors:  F G Winder; P B Collins; D Whelan
Journal:  J Gen Microbiol       Date:  1971-06

6.  Isolation, characterization, and function of 6-mycolyl-6'-acetyltrehalose in the H37Ra strain of Myocobacterium tuberculosis.

Authors:  K Takayama; E L Armstrong
Journal:  Biochemistry       Date:  1976-01-27       Impact factor: 3.162

7.  Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis.

Authors:  K Takayama; L Wang; H L David
Journal:  Antimicrob Agents Chemother       Date:  1972-07       Impact factor: 5.191

8.  EFFECT OF ETHAMBUTOL ON NUCLEIC ACID METABOLISM IN MYCOBACTERIUM SMEGMATIS AND ITS REVERSAL BY POLYAMINES AND DIVALENT CATIONS.

Authors:  M FORBES; N A KUCK; E A PEETS
Journal:  J Bacteriol       Date:  1965-05       Impact factor: 3.490

9.  Nonspecific ionic inhibition of ethambutol binding by Mycobacterium smegmatis.

Authors:  W H Beggs; F A Andrews
Journal:  Antimicrob Agents Chemother       Date:  1973-08       Impact factor: 5.191

10.  Effect of ethambutol on the viable cell count in Mycobacterium smegmatis.

Authors:  J O Kilburn; J Greenberg
Journal:  Antimicrob Agents Chemother       Date:  1977-03       Impact factor: 5.191
  10 in total
  34 in total

Review 1.  Treatment of pulmonary disease caused by opportunist mycobacteria.

Authors:  J Banks
Journal:  Thorax       Date:  1989-06       Impact factor: 9.139

2.  Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis.

Authors:  S V Ramaswamy; A G Amin; S Göksel; C E Stager; S J Dou; H El Sahly; S L Moghazeh; B N Kreiswirth; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

3.  Nucleotide polymorphism associated with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis.

Authors:  S Srivastava; A Garg; A Ayyagari; K K Nyati; T N Dhole; S K Dwivedi
Journal:  Curr Microbiol       Date:  2006-09-12       Impact factor: 2.188

4.  Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis.

Authors:  K Takayama; J O Kilburn
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

5.  Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.

Authors:  Ann S G Lee; Siti Noor Khadijah Othman; Yu Min Ho; Sin Yew Wong
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

Review 6.  Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.

Authors:  Sumit Chakraborty; Kyu Y Rhee
Journal:  Cold Spring Harb Perspect Med       Date:  2015-04-15       Impact factor: 6.915

Review 7.  The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan.

Authors:  Luke J Alderwick; James Harrison; Georgina S Lloyd; Helen L Birch
Journal:  Cold Spring Harb Perspect Med       Date:  2015-03-27       Impact factor: 6.915

8.  Activity of subinhibitory concentrations of dapsone alone and in combination with cell-wall inhibitors against Mycobacterium avium complex organisms.

Authors:  N Rastogi; K S Goh; V Labrousse
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1993-12       Impact factor: 3.267

9.  Effects of antituberculosis and antileprosy drugs on mycobacteriophage D29 growth.

Authors:  H L David; S Clavel; F Clement; J Moniz-Pereira
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

10.  Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis.

Authors:  N Rastogi; K S Goh; H L David
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191
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