Literature DB >> 15504879

Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.

Ann S G Lee1, Siti Noor Khadijah Othman, Yu Min Ho, Sin Yew Wong.   

Abstract

Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis, namely, an ATG-->ATM substitution resulting in M306I, G406N, and the novel alterations M423I and A659T.

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Year:  2004        PMID： 15504879      PMCID： PMC525425          DOI： 10.1128/AAC.48.11.4447-4449.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  32 in total

1.  Characterization of IS6110 restriction fragment length polymorphism patterns and mechanisms of antimicrobial resistance for multidrug-resistant isolates of Mycobacterium tuberculosis from a major reference hospital in Assiut, Egypt.

Authors:  S Abbadi; H G Rashed; G P Morlock; C L Woodley; O El Shanawy; R C Cooksey
Journal:  J Clin Microbiol       Date:  2001-06       Impact factor: 5.948

2.  Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis.

Authors:  K Takayama; J O Kilburn
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

3.  Detection of ethambutol-resistant Mycobacterium tuberculosis strains by multiplex allele-specific PCR assay targeting embB306 mutations.

Authors:  Igor Mokrousov; Olga Narvskaya; Elena Limeschenko; Tatiana Otten; Boris Vyshnevskiy
Journal:  J Clin Microbiol       Date:  2002-05       Impact factor: 5.948

4.  Mutations in the embB locus among Korean clinical isolates of Mycobacterium tuberculosis resistant to ethambutol.

Authors:  Hye Young Lee; Han Jung Myoung; Hye Eun Bang; Gill-Han Bai; Sang-Jae Kim; Joo Deuk Kim; Sang-Nae Cho
Journal:  Yonsei Med J       Date:  2002-02       Impact factor: 2.759

5.  Inhibition by ethambutol of mycolic acid transfer into the cell wall of Mycobacterium smegmatis.

Authors:  K Takayama; E L Armstrong; K A Kunugi; J O Kilburn
Journal:  Antimicrob Agents Chemother       Date:  1979-08       Impact factor: 5.191

6.  Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates from Monterrey, Mexico.

Authors:  Srinivas V Ramaswamy; Shu-Jun Dou; Adrian Rendon; Zhenhua Yang; M Donald Cave; Edward A Graviss
Journal:  J Med Microbiol       Date:  2004-02       Impact factor: 2.472

7.  Molecular analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with persistent disease in the Khartoum region of Sudan.

Authors:  G S Sharaf-Eldin; N S Saeed; M E Hamid; A M Jordaan; G D Van der Spuy; R M Warren; P D Van Helden; T C Victor
Journal:  J Infect       Date:  2002-05       Impact factor: 6.072

8.  [Clinical application and evaluation of the detection of five drugs resistance genes in Mycobacterium tuberculosis].

Authors:  Wei Wang; Hongmin Li; Xueqiong Wu; Ansheng Wang; Zhongyuan Wang; Jinwei Liu; Hongbing Chen; Minggui Lin; Jinhe Wang; Yixiu Ye; Sumei Li
Journal:  Zhonghua Jie He He Hu Xi Za Zhi       Date:  2002-11

9.  Detection of embB306 mutations in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis from Northwestern Russia: implications for genotypic resistance testing.

Authors:  Igor Mokrousov; Tatiana Otten; Boris Vyshnevskiy; Olga Narvskaya
Journal:  J Clin Microbiol       Date:  2002-10       Impact factor: 5.948

10.  Detection of katG Ser315Thr substitution in respiratory specimens from patients with isoniazid-resistant Mycobacterium tuberculosis using PCR-RFLP.

Authors:  Eric Tung-Yiu Leung; Kai-Man Kam; Agatha Chiu; Pak-Leung Ho; Wing-Hong Seto; Kwok-Yung Yuen; Wing-Cheong Yam
Journal:  J Med Microbiol       Date:  2003-11       Impact factor: 2.472
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  23 in total

1.  Mutations within embCAB Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China.

Authors:  Qing Sun; Tong-Yang Xiao; Hai-Can Liu; Xiu-Qin Zhao; Zhi-Guang Liu; Ya-Nan Li; Hao Zeng; Li-Li Zhao; Kang-Lin Wan
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

2.  Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China.

Authors:  Ruiru Shi; Jianyuan Zhang; Koji Otomo; Guolong Zhang; Isamu Sugawara
Journal:  Antimicrob Agents Chemother       Date:  2007-09-10       Impact factor: 5.191

3.  Whole genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis Beijing isolates from an outbreak in Thailand.

Authors:  Sanjib Mani Regmi; Angkana Chaiprasert; Supasak Kulawonganunchai; Sissades Tongsima; Olabisi Oluwabukola Coker; Therdsak Prammananan; Wasna Viratyosin; Iyarit Thaipisuttikul
Journal:  Mol Genet Genomics       Date:  2015-04-24       Impact factor: 3.291

4.  Molecular Analysis of the embCAB Locus and embR Gene Involved in Ethambutol Resistance in Clinical Isolates of Mycobacterium tuberculosis in France.

Authors:  Florence Brossier; Wladimir Sougakoff; Christine Bernard; Matthieu Petrou; Karine Adeyema; Anne Pham; Diane Amy de la Breteque; Marine Vallet; Vincent Jarlier; Christophe Sola; Nicolas Veziris
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

5.  Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates.

Authors:  Claudia Plinke; Sabine Rüsch-Gerdes; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

6.  Mutation at embB codon 306, a potential marker for the identification of multidrug resistance associated with ethambutol in Mycobacterium tuberculosis.

Authors:  Betzaida Cuevas-Córdoba; Dulce María Juárez-Eusebio; Raquel Almaraz-Velasco; Raquel Muñiz-Salazar; Rafael Laniado-Laborin; Roberto Zenteno-Cuevas
Journal:  Antimicrob Agents Chemother       Date:  2015-06-29       Impact factor: 5.191

7.  Association between embB Codon 306 Mutations, Phenotypic Resistance Profiles, and Genotypic Characterization in Clinical Mycobacterium tuberculosis Isolates from Hebei, China.

Authors:  Yanan Li; Yuling Wang; Zhi Zhang; Huixia Gao; Haibin Wang; Jinfeng Cao; Shumin Zhang; Yuzhen Liu; Jianhua Lu; Zungui Xu; Erhei Dai
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

8.  Mutations at embB codon 306 are an important molecular indicator of ethambutol resistance in Mycobacterium tuberculosis.

Authors:  Angela M Starks; Aysel Gumusboga; Bonnie B Plikaytis; Thomas M Shinnick; James E Posey
Journal:  Antimicrob Agents Chemother       Date:  2008-12-22       Impact factor: 5.191

9.  Allelic exchange and mutant selection demonstrate that common clinical embCAB gene mutations only modestly increase resistance to ethambutol in Mycobacterium tuberculosis.

Authors:  Hassan Safi; Robert D Fleischmann; Scott N Peterson; Marcus B Jones; Behnam Jarrahi; David Alland
Journal:  Antimicrob Agents Chemother       Date:  2009-10-12       Impact factor: 5.191

Review 10.  Diagnostic accuracy of a molecular drug susceptibility testing method for the antituberculosis drug ethambutol: a systematic review and meta-analysis.

Authors:  Song Cheng; Zhenling Cui; Yuanyuan Li; Zhongyi Hu
Journal:  J Clin Microbiol       Date:  2014-06-04       Impact factor: 5.948
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