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Literature DB >> 25877396

Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.

Abstract

Modern tuberculosis (TB) chemotherapy is widely viewed as a crowning triumph of anti-infectives research. However, only one new TB drug has entered clinical practice in the past 40 years while drug resistance threatens to further destabilize the pandemic. Here, we review a brief history of TB drug development, focusing on the evolution of mechanism(s)-of-action studies and key conceptual barriers to rational, mechanism-based drugs.

Entities: Disease

Mesh：

Substances：

Year: 2015 PMID： 25877396 PMCID： PMC4526730 DOI： 10.1101/cshperspect.a021147

Source DB: PubMed Journal: Cold Spring Harb Perspect Med ISSN： 2157-1422 Impact factor: 6.915

88 in total

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Journal: Tuberculosis (Edinb) Date: 2008-08 Impact factor: 3.131

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Journal: J Bacteriol Date: 1962-11 Impact factor: 3.490

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Journal: Antimicrob Agents Chemother Date: 1972-12 Impact factor: 5.191

9. Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China.

Authors: Dawei Shi; Liang Li; Yuling Zhao; Qiong Jia; Hui Li; Christopher Coulter; Qi Jin; Guofeng Zhu
Journal: J Antimicrob Chemother Date: 2011-07-21 Impact factor: 5.790

10. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.

Authors: Kevin Pethe; Patricia C Sequeira; Sanjay Agarwalla; Kyu Rhee; Kelli Kuhen; Wai Yee Phong; Viral Patel; David Beer; John R Walker; Jeyaraj Duraiswamy; Jan Jiricek; Thomas H Keller; Arnab Chatterjee; Mai Ping Tan; Manjunatha Ujjini; Srinivasa P S Rao; Luis Camacho; Pablo Bifani; Puiying A Mak; Ida Ma; S Whitney Barnes; Zhong Chen; David Plouffe; Pamela Thayalan; Seow Hwee Ng; Melvin Au; Boon Heng Lee; Bee Huat Tan; Sindhu Ravindran; Mahesh Nanjundappa; Xiuhua Lin; Anne Goh; Suresh B Lakshminarayana; Carolyn Shoen; Michael Cynamon; Barry Kreiswirth; Veronique Dartois; Eric C Peters; Richard Glynne; Sydney Brenner; Thomas Dick
Journal: Nat Commun Date: 2010-08-24 Impact factor: 14.919

23 in total

Review 1. Novel Approaches for the Treatment of Pulmonary Tuberculosis.

Authors: Zhi Ming Tan; Gui Ping Lai; Manisha Pandey; Teerapol Srichana; Mallikarjuna Rao Pichika; Bapi Gorain; Subrat Kumar Bhattamishra; Hira Choudhury
Journal: Pharmaceutics Date: 2020-12-10 Impact factor: 6.321

Review 2. Emerging Approaches to Tuberculosis Drug Development: At Home in the Metabolome.

Authors: Robert S Jansen; Kyu Y Rhee
Journal: Trends Pharmacol Sci Date: 2017-02-03 Impact factor: 14.819

Review 3. Targeting Phenotypically Tolerant Mycobacterium tuberculosis.

Authors: Ben Gold; Carl Nathan
Journal: Microbiol Spectr Date: 2017-01

Review 4. Learning from the past for TB drug discovery in the future.

Authors: Katarína Mikušová; Sean Ekins
Journal: Drug Discov Today Date: 2016-10-04 Impact factor: 7.851

5. Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics.

Authors: James Peek; Bimal Koirala; Sean F Brady
Journal: Bioorg Med Chem Lett Date: 2021-11-30 Impact factor: 2.823

6. Very-Rapidly Dissolving Printlets of Isoniazid Manufactured by SLS 3D Printing: In Vitro and In Vivo Characterization.

Authors: Tahir Khuroo; Eman M Mohamed; Sathish Dharani; Canberk Kayalar; Tanil Ozkan; Mathew A Kuttolamadom; Ziyaur Rahman; Mansoor A Khan
Journal: Mol Pharm Date: 2022-06-01 Impact factor: 5.364

Review 7. β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.

Authors: Jed F Fisher; Shahriar Mobashery
Journal: Cold Spring Harb Perspect Med Date: 2016-05-02 Impact factor: 6.915

8. Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.

Authors: Zhe Wang; Vijay Soni; Gwendolyn Marriner; Takushi Kaneko; Helena I M Boshoff; Clifton E Barry; Kyu Y Rhee
Journal: Proc Natl Acad Sci U S A Date: 2019-09-09 Impact factor: 11.205

Review 9. Recent Progress and Challenges for Drug-Resistant Tuberculosis Treatment.

Authors: Filia Stephanie; Mutiara Saragih; Usman Sumo Friend Tambunan
Journal: Pharmaceutics Date: 2021-04-21 Impact factor: 6.321

Review 10. Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery.

Authors: Divya Awasthi; Joel S Freundlich
Journal: Trends Microbiol Date: 2017-06-13 Impact factor: 17.079