Literature DB >> 448292

Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion.

T L Delovitch, B H Barber.   

Abstract

Sequential immunoprecipitation, two-dimensional gel electrophoresis and peptide mapping analyses of B10A(3R), 35S-methionine-labeled, I-EC subregion products were performed. Evidence is presented here for the presence of two structurally homologous, but nonidentical, gene products of the I-EC subregion. These two Ia molecules are independently immunoprecipitable, identical in molecular size and charge, but differ by approximately equal to 20% in their peptides obtained by partial digestion with Staphylococcus aureus protease V8.

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Year:  1979        PMID： 448292      PMCID： PMC2185616          DOI： 10.1084/jem.150.1.100

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

1.  Selective expression of separate I-region loci in functionally different lymphocyte subpopulations.

Authors:  D B Murphy; K Okumura; L A Herzenberg; L A Herzenberg; H O McDevitt
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

2.  Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.

Authors:  D C Shreffler; C S David; S E Cullen; J A Frelinger; J E Niederhuber
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

3.  Immunochemical characterization of the Ly-8.2 murine lymphocyte alloantigen: possible relationship to actin.

Authors:  T L Delovitch; A Fegelman; B H Barber; J A Frelinger
Journal:  J Immunol       Date:  1979-01       Impact factor: 5.422

4.  Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

Authors:  D W Cleveland; S G Fischer; M W Kirschner; U K Laemmli
Journal:  J Biol Chem       Date:  1977-02-10       Impact factor: 5.157

5.  Murine Ia antigens: identification and mapping of Ia.23 and further definition of the I-E subregion.

Authors:  C S David; S E Cullen
Journal:  J Immunol       Date:  1978-05       Impact factor: 5.422

6.  Expression of murine Ia antigens during embryonic development.

Authors:  T L Delovitch; J L Press; H O McDevitt
Journal:  J Immunol       Date:  1978-03       Impact factor: 5.422

7.  Two-gene control of the expression of a murine Ia antigen.

Authors:  P P Jones; D B Murphy; H O McDevitt
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307

8.  Immunochemical evidence for three Ia loci in the I-region of the H-2 complex.

Authors:  T L Delovitch; D B Murphy; H O McDevitt
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307

9.  A new lymphocyte-activating determinant locus expressed on T cells, and mapping in I-C subregion.

Authors:  K Okuda; C S David
Journal:  J Exp Med       Date:  1978-04-01       Impact factor: 14.307

10.  Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.

Authors:  P P Jones
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307
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  11 in total

1.  Identification on I-Ak molecules of a functional site recognized by proliferating T-lymphocytes.

Authors:  P C Dubreuil; D Z Birnbaum; D H Caillol; F A Lemonnier
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

2.  Biochemical evidence for multiple I-E Ia molecules.

Authors:  W P Lafuse; P S Corser; C S David
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

3.  Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: evidence for a single type of I-E molecule in homozygotes.

Authors:  S E Cullen; D C Shreffler; C S Kindle; C S David
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

4.  Clonal analysis of B- and T-cell responses to Ia antigens. I. Topology of epitope regions on I-Ak and I-Ek molecules analyzed with 35 monoclonal alloantibodies.

Authors:  M Pierres; C Devaux; M Dosseto; S Marchetto
Journal:  Immunogenetics       Date:  1981-12       Impact factor: 2.846

5.  Murine T cell Ia antigens: specificity Iat.46 maps in I-J to I-E chromosomal segment of H-2 complex.

Authors:  C E Hayes; J M Maier
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

6.  Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules.

Authors:  R Tosi; N Tanigaki; R Sorrentino; P van Mourik; P Ivanyi
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

7.  Evidence for unequal crossing over within the mouse T/t complex.

Authors:  L M Silver; M White; K Artzt
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

8.  Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.

Authors:  N Tanigaki; R Tosi; D Pressman; G B Ferrara
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

9.  Structure of murine Ia antigens. Two dimensional electrophoretic analyses and high pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide.

Authors:  M McMillan; J A Frelinger; P P Jones; D B Murphy; H O McDevitt; L Hood
Journal:  J Exp Med       Date:  1981-04-01       Impact factor: 14.307

10.  Role of Ia antigens in graft vs. host reactions. II. Molecular and functional analysis of T cell alloreactivity by the characterization of host Ia antigens on alloactivated donor T cells.

Authors:  T L Delovitch; J F Harris; R Battistella; K Kaufman
Journal:  J Exp Med       Date:  1982-01-01       Impact factor: 14.307
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