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Literature DB >> 77304

A new lymphocyte-activating determinant locus expressed on T cells, and mapping in I-C subregion.

Abstract

A new lymphocyte-activating determinant (Lad) locus expressed on T cells was identified, mapping in the I-C subregions of H-2k and H-2d haplotypes. The mixed lymphocyte reaction stimulation could be inhibited by anti-Ia sera made in strains incompatible for this chromosomal segment. Experiments with purified lymphocyte cell populations suggested that this Lad locus was expressed on T cells. Further, only purified T cells were able to remove the inhibiting activity from the anti-Ia sera. I-C subregion gene(s) seem to code for products selectively expressed on a subpopulation of T cells.

Entities: Gene

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Year: 1978 PMID： 77304 PMCID： PMC2184250 DOI： 10.1084/jem.147.4.1028

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

18 in total

9. Regulatory mechanisms in cell-mediated immune responses. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions.

Authors: S S Rich; R R Rich
Journal: J Exp Med Date: 1976-03-01 Impact factor: 14.307

10. Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.

Authors: S S Rich; R R Rich
Journal: J Exp Med Date: 1976-11-02 Impact factor: 14.307

6 in total

4. Regulatory mechanisms in cell-mediated immune responses. VIII. Differential expression of I-region determinants by suppressor cells and their targets in suppression of mixed leukocyte reactions.

Authors: S S Rich; C S David
Journal: J Exp Med Date: 1979-11-01 Impact factor: 14.307

5. Murine T cell Ia antigens: specificity Iat.46 maps in I-J to I-E chromosomal segment of H-2 complex.

Authors: C E Hayes; J M Maier
Journal: Proc Natl Acad Sci U S A Date: 1980-11 Impact factor: 11.205

6. Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.

Authors: S S Rich; C S David; R R Rich
Journal: J Exp Med Date: 1979-01-01 Impact factor: 14.307

6 in total

A new lymphocyte-activating determinant locus expressed on T cells, and mapping in I-C subregion.

1. Development of B lymphocytes-1,2.

2. Characterization of immune response and mixed lymphocyte reactions in selected intra-H-2 recombinant strains.

3. Complementation of H-2-linked Ir genes in the mouse.

4. Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.

5. A major role for the Ir-1 region of the mouse H-2 complex in the mixed leukocyte reaction.

6. Comparison of mitomycin C and X-irradiation as blocking agents in one-way mixed leucocyte cultures.

7. New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.

8. The role of gene products of the I-J subregion in mixed lymphocyte reactions.

9. Regulatory mechanisms in cell-mediated immune responses. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions.

10. Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.

1. Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion.

2. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex.

3. Production of a cytotoxic Ia.6-specific antibody.

4. Regulatory mechanisms in cell-mediated immune responses. VIII. Differential expression of I-region determinants by suppressor cells and their targets in suppression of mixed leukocyte reactions.

5. Murine T cell Ia antigens: specificity Iat.46 maps in I-J to I-E chromosomal segment of H-2 complex.

6. Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.