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Literature DB >> 72779

Immunochemical evidence for three Ia loci in the I-region of the H-2 complex.

T L Delovitch, D B Murphy, H O McDevitt.

Abstract

Sequential immunoprecipitation analyses of Ia antigens were performed with 125I-labeled B10, B10.A(3R), and B10.A(5R) spleen cell lysates. The results suggest the presence of one I-region associated (Ia) locus (Ia-1) in the I-A subregion. In addition, they indicate that two Ia loci map between the I-J and S regions. One locus, Ia-5, maps in the I-E subregion. The second locus, most likely Ia-3, maps in either the I-E or I-C subregion. Taken together, the data demonstrate that at least three Ia loci in the I-region of the H-2 complex code for molecules detectable by immunoprecipitation.

Entities: Chemical Gene

Mesh：

Substances：
Epitopes

Year: 1977 PMID： 72779 PMCID： PMC2181892 DOI： 10.1084/jem.146.6.1549

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. Serologic and biochemical studies of the Ia system of the mouse H-2 gene complex. Further evidence for I-C subregion.

Authors: C S David; S E Cullen; D B Murphy
Journal: J Immunol Date: 1975-04 Impact factor: 5.422

2. High resolution two-dimensional electrophoresis of proteins.

Authors: P H O'Farrell
Journal: J Biol Chem Date: 1975-05-25 Impact factor: 5.157

3. Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.

Authors: D C Shreffler; C S David; S E Cullen; J A Frelinger; J E Niederhuber
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

4. Chemical characterization of products of the H-2 complex.

Authors: J Silver; J M Cecka; M McMillan; L Hood
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

5. Isolation of glycoproteins from pig lymphocyte plasma membrane using Lens culinaris phytohemagglutinin.

Authors: M J Hayman; M J Crumpton
Journal: Biochem Biophys Res Commun Date: 1972-05-26 Impact factor: 3.575

6. Selective enzyme purification by affinity chromatography.

Authors: P Cuatrecasas; M Wilchek; C B Anfinsen
Journal: Proc Natl Acad Sci U S A Date: 1968-10 Impact factor: 11.205

7. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

8. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

Authors: D C Shreffler; C S David
Journal: Adv Immunol Date: 1975 Impact factor: 3.543

7. Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: evidence for a single type of I-E molecule in homozygotes.

Authors: S E Cullen; D C Shreffler; C S Kindle; C S David
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

8. Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.

Authors: S S Rich; C S David; R R Rich
Journal: J Exp Med Date: 1979-01-01 Impact factor: 14.307

9. T-cell-specific murine Ia antigens: serology of I-J and I-E subregion specificities.

Authors: C E Hayes; F H Bach
Journal: J Exp Med Date: 1978-09-01 Impact factor: 14.307

9 in total

Immunochemical evidence for three Ia loci in the I-region of the H-2 complex.

1. Serologic and biochemical studies of the Ia system of the mouse H-2 gene complex. Further evidence for I-C subregion.

2. High resolution two-dimensional electrophoresis of proteins.

3. Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.

4. Chemical characterization of products of the H-2 complex.

5. Isolation of glycoproteins from pig lymphocyte plasma membrane using Lens culinaris phytohemagglutinin.

6. Selective enzyme purification by affinity chromatography.

7. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

8. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

9. A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.

10. Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.

1. Identification of two Ia-like alloantigens on rabbit B lymphocytes.

2. Immunosuppressive ALS. II. Antibody to Ia antigens in heterologous anti-lymphocyte serum.

3. Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion.

4. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex.

5. Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.

6. Biochemical evidence for multiple I-E Ia molecules.

7. Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: evidence for a single type of I-E molecule in homozygotes.

8. Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.

9. T-cell-specific murine Ia antigens: serology of I-J and I-E subregion specificities.