Literature DB >> 302173

Selective expression of separate I-region loci in functionally different lymphocyte subpopulations.

D B Murphy, K Okumura, L A Herzenberg, L A Herzenberg, H O McDevitt.   

Abstract

Determinants controlled by separate loci mapping in the I region of the H-2 gene complex are selectively expressed on subpopulations of lymphocytes which play different roles in generating humoral responses. The Ia-4 locus, which marks a new I subregion, designated I-J, controls determinants found on allotype suppressor and normal (nonsuppressed) T lymphocytes. These determinants are not present on helper T lymphocytes or B lymphocytes. In contrast, the Ia-1 locus, which marks the I-A subregion, controls determinants present on B lymphocytes but not on suppressor or helper T lymphocytes. Another locus (subregion not known) controls determinants which distinguish helper T lymphocytes from suppressor T lymphocytes. Such selective expression suggests that the products of these loci may plan an integral role in lymphocyte interactions.

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Year:  1977        PMID： 302173     DOI： 10.1101/sqb.1977.041.01.057

Source DB:  PubMed          Journal:  Cold Spring Harb Symp Quant Biol        ISSN： 0091-7451


  10 in total

1.  Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion.

Authors:  T L Delovitch; B H Barber
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307

2.  T cells in a suppressor circuit and non-T:non-B cells bear different I-J determinants.

Authors:  D B Murphy; K Yamauchi; S Habu; D D Eardley; R K Gershon
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

3.  Clonal evolution of myeloma cells leads to quantitative changes in immunoglobulin secretion and surface antigen expression.

Authors:  P J Leibson; M R Loken; S Panem; H Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

4.  Association of I-J determinants with lipomodulin/macrocortin.

Authors:  P Jardieu; M Akasaki; K Ishizaka
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

5.  The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens.

Authors:  G J Prud'homme; U Sohn; T L Delovitch
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307

6.  In vitro analysis of allogeneic lymphocyte interaction. II. I-region control of the activity of a B-cell-derived H-2-restricted allogeneic effect factor and its receptor during B-cell activation.

Authors:  T L Delovitch; J Biggin; F Y Fung
Journal:  J Exp Med       Date:  1978-04-01       Impact factor: 14.307

7.  Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.

Authors:  J E Swierkosz; P Marrack; J W Kappler
Journal:  J Exp Med       Date:  1979-12-01       Impact factor: 14.307

8.  Generation of primary cytotoxic lymphocytes against non-major histocompatibility complex antigens by anti-Ia serum plus complement-treated lymphocytes.

Authors:  C E Hayes; S Macphail; F H Bach
Journal:  J Exp Med       Date:  1980-05-01       Impact factor: 14.307

9.  Immunological dissection of human Ia molecules.

Authors:  R Tosi; N Tanigaki; D Centis; G B Ferrara; D Pressman
Journal:  J Exp Med       Date:  1978-12-01       Impact factor: 14.307

10.  Thymic selection of H-2-incompatible bone marrow cells in SCID mice. Differences in T help for induction of B cell IgG responses versus cytotoxic T cells.

Authors:  R M Zinkernagel; E Rüedi; A Althage; H Hengartner; G Reimann
Journal:  J Exp Med       Date:  1988-09-01       Impact factor: 14.307
  10 in total

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