Literature DB >> 4360718

Inhibition by ricin of protein synthesis in vitro: 60 S ribosomal subunit as the target of the toxin.

S Sperti, L Montanaro, A Mattioli, F Stirpe.   

Abstract

Poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes is strongly inhibited by ricin. Experiments involving hybridization between subunits derived from normal and ricin-treated ribosomes demonstrate that the 60S subunit is the site of action of the toxin. The toxin inactivates the 60S subunit independently of the presence of the 40S subunit.

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Year:  1973        PMID： 4360718      PMCID： PMC1166019          DOI： 10.1042/bj1360813

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Ricin - a potent inhibitor of protein synthesis.

Authors:  S Olsnes; A Pihl
Journal:  FEBS Lett       Date:  1972-02-15       Impact factor: 4.124

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Thiostrepton: a ribosomal inhibitor of translocation.

Authors:  S Pestka
Journal:  Biochem Biophys Res Commun       Date:  1970-08-11       Impact factor: 3.575

4.  Comparison of amino acid polymerization factors isolated from rat liver and rabbit reticulocytes.

Authors:  L Felicetti; F Lipmann
Journal:  Arch Biochem Biophys       Date:  1968-05       Impact factor: 4.013

5.  Ribosomes, G-factor and siomycin.

Authors:  J Modolell; D Vazquez; R E Monro
Journal:  Nat New Biol       Date:  1971-03-24

6.  The peptidyl transferase activity of ribosomes.

Authors:  R E Monro; T Staehelin; M L Celma; D Vazquez
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1969

7.  Treatment of abrin and ricin with -mercaptoethanol opposite effects on their toxicity in mice and their ability to inhibit protein synthesis in a cell-free system.

Authors:  S Olsnes; A Pihl
Journal:  FEBS Lett       Date:  1972-11-15       Impact factor: 4.124

8.  Interaction of polypeptide chain elongation factors with rat liver ribosomal subunits.

Authors:  P Rao; K Moldave
Journal:  J Mol Biol       Date:  1969-12-28       Impact factor: 5.469

9.  Dissociation of mammalian polyribosomes into subunits by puromycin.

Authors:  G Blobel; D Sabatini
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205

10.  The function of 80 S ribosomal subunits and effects of some antibiotics.

Authors:  D Vazquez; E Battaner; R Neth; G Heller; R E Monro
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1969
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  33 in total

1.  Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurination.

Authors:  Xiao-Ping Li; Przemyslaw Grela; Dawid Krokowski; Marek Tchórzewski; Nilgun E Tumer
Journal:  J Biol Chem       Date:  2010-10-25       Impact factor: 5.157

2.  Ricin and modeccin do not inhibit the elongation factor 1-dependent binding of aminoacyl-tRNA to ribosomes.

Authors:  S Sperti; L Montanaro
Journal:  Biochem J       Date:  1979-01-15       Impact factor: 3.857

3.  Relationship between elongation factor I- and elongation factor II- dependent guanosine triphosphatase activities of ribosomes. Inhibition of both activities by ricin.

Authors:  S Sperti; L Montanaro; A Mattioli; G Testoni
Journal:  Biochem J       Date:  1975-06       Impact factor: 3.857

4.  Inhibition by ricin of protein synthesis in vitro. Inhibition of the binding of elongation factor 2 and of adenosine diphosphate-ribosylated elongation factor 2 to ribosomes.

Authors:  L Montanaro; S Sperti; A Mattioli; G Testoni; F Stirpe
Journal:  Biochem J       Date:  1975-01       Impact factor: 3.857

5.  Characterization of a cDNA encoding ricin E, a hybrid ricin-Ricinus communis agglutinin gene from the castor plant Ricinus communis.

Authors:  B F Ladin; E E Murray; A C Halling; K C Halling; N Tilakaratne; G L Long; L L Houston; R F Weaver
Journal:  Plant Mol Biol       Date:  1987-05       Impact factor: 4.076

6.  Studies on the proteins from the seeds of Croton tiglium and of Jatropha curcas. Toxic properties and inhibition of protein synthesis in vitro.

Authors:  F Stirpe; A Pession-Brizzi; E Lorenzoni; P Strocchi; L Montanaro; S Sperti
Journal:  Biochem J       Date:  1976-04-15       Impact factor: 3.857

7.  Inhibition of protein synthesis in vitro by proteins from the seeds of Momordica charantia (bitter pear melon).

Authors:  L Barbieri; M Zamboni; E Lorenzoni; L Montanaro; S Sperti; F Stirpe
Journal:  Biochem J       Date:  1980-02-15       Impact factor: 3.857

8.  Ribosomal core-particles as the target of ricin.

Authors:  M Zamboni; G Battelli; L Montanaro; S Sperti
Journal:  Biochem J       Date:  1981-03-15       Impact factor: 3.857

9.  Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Authors:  Xiao-Ping Li; Peter C Kahn; Jennifer Nielsen Kahn; Przemyslaw Grela; Nilgun E Tumer
Journal:  J Biol Chem       Date:  2013-09-03       Impact factor: 5.157

10.  High-pressure-liquid-chromatographic and fluorimetric methods for the determination of adenine released from ribosomes by ricin and gelonin.

Authors:  M Zamboni; M Brigotti; F Rambelli; L Montanaro; S Sperti
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857
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