Literature DB >> 173282

Relationship between elongation factor I- and elongation factor II- dependent guanosine triphosphatase activities of ribosomes. Inhibition of both activities by ricin.

S Sperti, L Montanaro, A Mattioli, G Testoni.   

Abstract

The elongation factor 1- and elongation factor 2-dependent GTPase (guanosine triphosphatase) activities of ribosomes are inhibited by ricin, a toxic protein known to inactivate the 60S ribosomal subunit. It is suggested that also in eukaryotic ribosomes a "GTPase site', located on the larger subunit, is common to the two elongation factors.

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Year:  1975        PMID： 173282      PMCID： PMC1165562          DOI： 10.1042/bj1480447

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

1.  Inhibition by ricin of protein synthesis in vitro. Inhibition of the binding of elongation factor 2 and of adenosine diphosphate-ribosylated elongation factor 2 to ribosomes.

Authors:  L Montanaro; S Sperti; A Mattioli; G Testoni; F Stirpe
Journal:  Biochem J       Date:  1975-01       Impact factor: 3.857

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Inhibition by ricin of protein synthesis in vitro: 60 S ribosomal subunit as the target of the toxin.

Authors:  S Sperti; L Montanaro; A Mattioli; F Stirpe
Journal:  Biochem J       Date:  1973-11       Impact factor: 3.857

4.  The ribosomal subunit requirements for GTP hydrolysis by reticulocyte polypeptide elongation factors EF-1 and EF-2.

Authors:  W McKeehan
Journal:  Biochem Biophys Res Commun       Date:  1972-09-05       Impact factor: 3.575

5.  Thiostrepton: a ribosomal inhibitor of translocation.

Authors:  S Pestka
Journal:  Biochem Biophys Res Commun       Date:  1970-08-11       Impact factor: 3.575

6.  Comparison of amino acid polymerization factors isolated from rat liver and rabbit reticulocytes.

Authors:  L Felicetti; F Lipmann
Journal:  Arch Biochem Biophys       Date:  1968-05       Impact factor: 4.013

7.  Conformational control of the interaction of eukaryotic elongation factors EF-1 and EF-2 with ribosomes.

Authors:  C Nombela; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

8.  Competition between the elongation factors 1 and 2, and phenylalanyl transfer ribonucleic acid for the ribosomal binding sites in a polypeptide-synthesizing system from brain.

Authors:  D Richter
Journal:  J Biol Chem       Date:  1973-04-25       Impact factor: 5.157

9.  Evidence for aminoacyl-tRNA binding, peptide bond synthesis, and translocase activities in the aminoacyl transfer reaction.

Authors:  L Skogerson; K Moldave
Journal:  Arch Biochem Biophys       Date:  1968-05       Impact factor: 4.013

10.  Inhibition by siomycin and thiostrepton of both aminoacyl-tRNA and factor G binding to ribosomes.

Authors:  J Modolell; B Cabrer; A Parmeggiani; D Vazquez
Journal:  Proc Natl Acad Sci U S A       Date:  1971-08       Impact factor: 11.205
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  12 in total

1.  Effects of osmolarity, ions and compatible osmolytes on cell-free protein synthesis.

Authors:  Maurizio Brigotti; Pier Giorgio Petronini; Domenica Carnicelli; Roberta R Alfieri; Mara A Bonelli; Angelo F Borghetti; Kenneth P Wheeler
Journal:  Biochem J       Date:  2003-01-15       Impact factor: 3.857

2.  Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation.

Authors:  Nina Clementi; Anna Chirkova; Barbara Puffer; Ronald Micura; Norbert Polacek
Journal:  Nat Chem Biol       Date:  2010-03-28       Impact factor: 15.040

3.  Effect of modeccin on the steps of peptide-chain elongation.

Authors:  L Montanaro; S Sperti; M Zamboni; M Denaro; G Testoni; A Gasperi-Campani; F Stirpe
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

4.  Ricin and modeccin do not inhibit the elongation factor 1-dependent binding of aminoacyl-tRNA to ribosomes.

Authors:  S Sperti; L Montanaro
Journal:  Biochem J       Date:  1979-01-15       Impact factor: 3.857

5.  Inhibition of protein synthesis in vitro by crotins and ricin. Effect on the steps of peptide chain elongation.

Authors:  S Sperti; L Montanaro; A Mattioli; G Testoni; F Stirpe
Journal:  Biochem J       Date:  1976-04-15       Impact factor: 3.857

6.  Ribosomal core-particles as the target of ricin.

Authors:  M Zamboni; G Battelli; L Montanaro; S Sperti
Journal:  Biochem J       Date:  1981-03-15       Impact factor: 3.857

7.  Effect of alpha-sarcin and ribosome-inactivating proteins on the interaction of elongation factors with ribosomes.

Authors:  M Brigotti; F Rambelli; M Zamboni; L Montanaro; S Sperti
Journal:  Biochem J       Date:  1989-02-01       Impact factor: 3.857

Review 8.  Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects.

Authors:  Artem V Domashevskiy; Dixie J Goss
Journal:  Toxins (Basel)       Date:  2015-01-28       Impact factor: 4.546

9.  Whole-Cell Multiparameter Assay for Ricin and Abrin Activity-Based Digital Holographic Microscopy.

Authors:  Efi Makdasi; Orly Laskar; Elad Milrot; Ofir Schuster; Shlomo Shmaya; Shmuel Yitzhaki
Journal:  Toxins (Basel)       Date:  2019-03-22       Impact factor: 4.546

10.  The low density receptor-related protein 1 plays a significant role in ricin-mediated intoxication of lung cells.

Authors:  Reut Falach; Anita Sapoznikov; Yoav Gal; Eytan Elhanany; Yentl Evgy; Ohad Shifman; Moshe Aftalion; Sharon Ehrlich; Shlomi Lazar; Tamar Sabo; Chanoch Kronman; Ohad Mazor
Journal:  Sci Rep       Date:  2020-06-02       Impact factor: 4.379
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