Literature DB >> 4146214

Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids.

C M Croce, G Litwack, H Koprowski.   

Abstract

The inducibility of tyrosine aminotransferase (EC 2.6.1.5) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8) and, therefore, can be assigned to the X chromosome.

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Year:  1973        PMID： 4146214      PMCID： PMC433473          DOI： 10.1073/pnas.70.4.1268

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA.

Authors:  G M Tomkins; T D Gelehrter; D Granner; D Martin; H H Samuels; E B Thompson
Journal:  Science       Date:  1969-12-19       Impact factor: 47.728

2.  Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

Authors:  E B Thompson; G M Tomkins; J F Curran
Journal:  Proc Natl Acad Sci U S A       Date:  1966-07       Impact factor: 11.205

3.  A rapid banding technique for human chromosomes.

Authors:  M Seabright
Journal:  Lancet       Date:  1971-10-30       Impact factor: 79.321

4.  Isoenzymes of hypoxanthine-guanine-phosphoribosyl transferase in a family with partial deficiency of the enzyme.

Authors:  B Bakay; W L Nyhan; N Fawcett; M D Kogut
Journal:  Biochem Genet       Date:  1972-08       Impact factor: 1.890

5.  Simplicity of mammalian regulatory systems inferred by single gene determination of sex phenotypes.

Authors:  S Ono
Journal:  Nature       Date:  1971-11-19       Impact factor: 49.962

6.  Cytological mapping of human X-linked genes by use of somatic cell hybrids involving an X-autosome translocation (mouse-hamster-human X-linked markers).

Authors:  K H Grzeschik; P W Allderdice; A Grzeschik; J M Opitz; O J Miller; M Siniscalco
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

7.  Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes.

Authors:  M C Weiss; M Chaplain
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

8.  Somatic cell genetic assignment of peptidase C and the Rh linkage group to chromosome A-1 in man.

Authors:  F Ruddle; F Ricciuti; F A McMorris; G Darlington; T Chen
Journal:  Science       Date:  1972-06-30       Impact factor: 47.728

9.  Expression of tyrosine aminotransferase activity in somatic-cell heterokaryons: evidence for negative control of enzyme expression.

Authors:  E B Thompson; T D Gelehrter
Journal:  Proc Natl Acad Sci U S A       Date:  1971-10       Impact factor: 11.205

10.  Cellular site of glucocorticoid-receptor complex formation.

Authors:  B B Levinson; J D Baxter; G G Rousseau; G M Tomkins
Journal:  Science       Date:  1972-01-14       Impact factor: 47.728
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  20 in total

1.  Somatic cell hybrids between mouse peritoneal macrophages and simian-virus-40-transformed human cells: II. Presence of human chromosome 7 carrying simin virus 40 genome in cells of tumors induced by hybrid cells.

Authors:  C M Croce; D Aden; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

2.  Banded karyotypes of H-4-IIE-C3 rat hepatoma cells grown in vitro.

Authors:  V T Mullen; C A Barnett
Journal:  In Vitro       Date:  1976-09

3.  Cholesteryl ester metabolism in tissue culture cells. I. Accumulation in Fu5AH rat hepatoma cells.

Authors:  G H Rothblat
Journal:  Lipids       Date:  1974-08       Impact factor: 1.880

4.  Chromosome assignment of the T-antigen gene of simian virus 40 in African green monkey cells transformed by adeno 7-SV40 hybrid.

Authors:  C M Croce; K Huebner; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

5.  Segregation of rat chromosomes in somatic cell hybrids between rat cells and HT 1080 human fibrosarcoma cells.

Authors:  G G D'Ancona; C M Croce
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

6.  Origin of fatty acids of cholesteryl ester accumulated by Fu5AH cells in culture.

Authors:  J M Rosen; G H Rothblat
Journal:  Lipids       Date:  1977-02       Impact factor: 1.880

7.  Assignment of the human gene for hexose-1-phosphate uridylyltransferase to chromosome 3.

Authors:  T A Tedesco; R Diamond; K G Orkwiszewski; H J Boedecker; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205

8.  Reexpression of the rat hypoxanthine phosphoribosyltransferase gene in rat-human hybrids.

Authors:  C M Croce; B Bakay; W L Nyhan; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1973-09       Impact factor: 11.205

9.  Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7.

Authors:  C M Croce; A J Girardi; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

10.  Restoration of the conversion of desmosterol to cholesterol in L-cells after hybridization with human fibroblasts.

Authors:  C M Croce; I Kieba; H Koprowski; M Molino; G H Rothblat
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205
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