Literature DB >> 4359325

Restoration of the conversion of desmosterol to cholesterol in L-cells after hybridization with human fibroblasts.

C M Croce, I Kieba, H Koprowski, M Molino, G H Rothblat.   

Abstract

Hybrids between different human cells (which synthesize cholesterol) and mouse cells (whose end-product of sterol synthesis is desmosterol) were analyzed for the ability to convert desmosterol to cholesterol. Conversion of [(14)C]desmosterol to cholesterol and incorporation of [(14)C]acetate into the end-product sterol were studied in the parental and hybrid cells. Concordant segregation of the conversion of desmosterol to cholesterol and the human chromosome F-20 was observed.

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Year:  1974        PMID： 4359325      PMCID： PMC387944          DOI： 10.1073/pnas.71.1.110

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  STUDIES ON BRAIN STEROLS IN NORMAL AND PATHOLOGICAL CONDITIONS.

Authors:  R PAOLETTI; R FUMAGALLI; E GROSSI; P PAOLETTI
Journal:  J Am Oil Chem Soc       Date:  1965-05       Impact factor: 1.849

2.  Induction of homokaryocyte, heterokaryocyte and hybrid formation by lysolecithin.

Authors:  C M Croce; W Sawicki; D Kritchevsky; H Koprowski
Journal:  Exp Cell Res       Date:  1971-08       Impact factor: 3.905

3.  Occurrence of desmosterol in tumors of the nervous system induced in the rat by nitrosourea derivatives.

Authors:  J F Weiss; E G Paoletti; P Paoletti; D Schiffer; A Fabiani
Journal:  Cancer Res       Date:  1970-08       Impact factor: 12.701

4.  The desmosterol reductase activity of rat brain during development.

Authors:  C H Hinse; S N Shah
Journal:  J Neurochem       Date:  1971-10       Impact factor: 5.372

5.  A rapid banding technique for human chromosomes.

Authors:  M Seabright
Journal:  Lancet       Date:  1971-10-30       Impact factor: 79.321

6.  Desmosterol in developing rat brain.

Authors:  D Kritchevsky; S A Tepper; N W DiTullio; W L Holmes
Journal:  J Am Oil Chem Soc       Date:  1965-12       Impact factor: 1.849

7.  The effect of serum components on sterol biosynthesis in L cells.

Authors:  G H Rothblat
Journal:  J Cell Physiol       Date:  1969-10       Impact factor: 6.384

8.  Desmosterol as the major sterol in L-cell mouse fibroblasts grown in sterol-free culture medium.

Authors:  G H Rothblat; C H Burns; R L Conner; J R Landrey
Journal:  Science       Date:  1970-08-28       Impact factor: 47.728

9.  Somatic cell genetic assignment of peptidase C and the Rh linkage group to chromosome A-1 in man.

Authors:  F Ruddle; F Ricciuti; F A McMorris; G Darlington; T Chen
Journal:  Science       Date:  1972-06-30       Impact factor: 47.728

10.  Loss of human genetic markers in man--Chinese hamster somatic cell hybrids.

Authors:  A Westerveld; R P Visser; P Meera Khan; D Bootsma
Journal:  Nat New Biol       Date:  1971-11-03
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  3 in total

Review 1.  The map of chromosome 20.

Authors:  N E Simpson
Journal:  J Med Genet       Date:  1988-12       Impact factor: 6.318

2.  Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase.

Authors:  S H Bae; Y K Paik
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

3.  Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.

Authors:  H R Waterham; J Koster; G J Romeijn; R C Hennekam; P Vreken; H C Andersson; D R FitzPatrick; R I Kelley; R J Wanders
Journal:  Am J Hum Genet       Date:  2001-08-22       Impact factor: 11.025
  3 in total

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