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Literature DB >> 408274

Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.

D Neumann-Haefelin, R Sundmacher, R Skoda, K Cantell.

Abstract

The prophylactic potency of topically applied human leukocyte interferon and human fibroblast interferon was compared in a monkey model with herpes simplex virus type 1-induced keratitis. Both interferons effectively prevented keratitis at 1.9 X 10(6) U of activity per ml but were ineffective at 1.9 X 10(3) U/ml. Slight differences between human leukocyte interferon and human fibroblast interferon observed at the level of 1.9 X 10(5) U/ml were not statistically significant.

Entities: Disease Gene Species

Mesh：

Substances：
Interferons

Year: 1977 PMID： 408274 PMCID： PMC421145 DOI： 10.1128/iai.17.2.468-470.1977

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

11 in total

1. Effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas.

Authors: D Neumann-Haefelin; R Sundmacher; B Sauter; H E Karges; K F Manthey
Journal: Infect Immun Date: 1975-07 Impact factor: 3.441

2. Distinct molecular species of human interferons: requirements for stabilzation and reactivation of human leukocyte and fibroblast interferons.

Authors: W E Stewart II; P De Somer; V G Edy; K Paucker; K Berg; C A Ogburn
Journal: J Gen Virol Date: 1975-03 Impact factor: 3.891

3. Effect of exogenous interferon on herpetic keratitis in rabbits and monkeys.

Authors: H E Kaufman; J Sugar; E D Varnell
Journal: Invest Ophthalmol Date: 1973-05

4. Letter: Interferon treatment of dendritic keratitis.

Authors: R Sundmacher; D Neumann-Haefelin; K Cantell
Journal: Lancet Date: 1976-06-26 Impact factor: 79.321

Review 5. Human leukocyte interferon: production, purification, stability, and animal experiments.

Authors: K Cantell; S Hirvonen; K E Mogensen; L Pyhälä
Journal: In Vitro Monogr Date: 1974

6. Topical therapy of ulcerative herpetic keratitis with human interferon.

Authors: B R Jones; D J Coster; M G Falcon; K Cantell
Journal: Lancet Date: 1976-07-17 Impact factor: 79.321

7. Successful treatment of dendritic keratitis with human leukocyte interferon. A controlled clinical study.

Authors: R Sundmacher; D Neumann-Haefelin; K Cantell
Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol Date: 1976-11-18

8. Two antigenically distinct species of human interferon.

Authors: E A Havell; B Berman; C A Ogburn; K Berg; K Paucker; J Vilcek
Journal: Proc Natl Acad Sci U S A Date: 1975-06 Impact factor: 11.205

9. Human fibroblast and leukocyte interferons show different dose-response curves in assay of cell protection.

Authors: V G Edy; A Billiau; P De Somer
Journal: J Gen Virol Date: 1976-05 Impact factor: 3.891

10. Interferon in treatment of dendritic keratitis in humans: a preliminary report.

Authors: R Sundmacher; D Neumann-Haefelin; K F Manthey; O Müller
Journal: J Infect Dis Date: 1976-06 Impact factor: 5.226

6 in total

1. Recombinant HuIFN-gamma prevents herpes simplex keratitis in African green monkeys: demonstration of synergism with recombinant HuIFN-alpha 2.

Authors: D Neumann-Haefelin; R Sundmacher; H Frey; W Merk
Journal: Med Microbiol Immunol Date: 1985 Impact factor: 3.402