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Literature DB >> 6158933

Failure of human fibroblast interferon to protect against rhinovirus infection.

G M Scott, S Reed, T Cartwright, D Tyrrell.

Abstract

Volunteers were treated with fibroblast interferon or placebo nose drops for four days. On the second day, they received a challenge with rhinovirus type 4. There was no difference in the clinical symptoms or viral shedding between the two groups. The possible reasons for this result are discussed.

Entities: Disease Species

Mesh：

Substances：
Placebos
Interferons

Year: 1980 PMID： 6158933 DOI： 10.1007/BF01317324

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

15 in total

1. Virus interference. I. The interferon.

Authors: A ISAACS; J LINDENMANN
Journal: Proc R Soc Lond B Biol Sci Date: 1957-09-12

2. Antiviral activity of intranasally applied human leukocyte interferon.

Authors: S B Greenberg; M W Harmon; P E Johnson; R B Couch
Journal: Antimicrob Agents Chemother Date: 1978-10 Impact factor: 5.191

3. Reagents which inhibit disulphide bond formation stabilize human fibroblast interferon.

Authors: T Cartwright; O Senussi; D Grady
Journal: J Gen Virol Date: 1977-08 Impact factor: 3.891

4. Distribution and removal of human serum albumin-technetium 99m instilled intranasally.

Authors: F Y Aoki; J C Crowley
Journal: Br J Clin Pharmacol Date: 1976-10 Impact factor: 4.335

5. Effect of human fibroblast interferon on vaccination in volunteers.

Authors: G M Scott; T Cartwright; G LeDu; D Dicker
Journal: J Biol Stand Date: 1978-01

6. Inhibition of respiratory virus infection by locally applied interferon.

Authors: T C Merigan; S E Reed; T S Hall; D A Tyrrell
Journal: Lancet Date: 1973-03-17 Impact factor: 79.321

7. Production of high-titered interferon in cultures of human diploid cells.

Authors: E A Havell; J Vilcek
Journal: Antimicrob Agents Chemother Date: 1972-12 Impact factor: 5.191

8. Hemagglutination-inhibition test in rhinovirus infections of volunteers.

Authors: S E Reed; T S Hall
Journal: Infect Immun Date: 1973-07 Impact factor: 3.441

9. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.

Authors: D Neumann-Haefelin; R Sundmacher; R Skoda; K Cantell
Journal: Infect Immun Date: 1977-08 Impact factor: 3.441

Failure of human fibroblast interferon to protect against rhinovirus infection.

1. Virus interference. I. The interferon.

2. Antiviral activity of intranasally applied human leukocyte interferon.

3. Reagents which inhibit disulphide bond formation stabilize human fibroblast interferon.

4. Distribution and removal of human serum albumin-technetium 99m instilled intranasally.

5. Effect of human fibroblast interferon on vaccination in volunteers.

6. Inhibition of respiratory virus infection by locally applied interferon.

7. Production of high-titered interferon in cultures of human diploid cells.

8. Hemagglutination-inhibition test in rhinovirus infections of volunteers.

9. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.

10. Recovery of applied human leukocyte interferon from the nasal mucosa of chimpanzees and humans.

Review 1. Interferons and interferon inducers: development of clinical usefulness and therapeutic promise.

2. Purified interferon as protection against rhinovirus infection.

Review 3. Antiviral therapy. Respiratory infections, genital herpes, and herpetic keratitis.

Review 4. The clinical application of fibroblast interferon--an overview.