Literature DB >> 3929044

Recombinant HuIFN-gamma prevents herpes simplex keratitis in African green monkeys: demonstration of synergism with recombinant HuIFN-alpha 2.

D Neumann-Haefelin, R Sundmacher, H Frey, W Merk.   

Abstract

Human interferon gamma (HuIFN-gamma) was found to prevent herpes-simplex virus (HSV 1) induced keratitis in monkey eyes, when administered topically at concentrations of greater than or equal to 3 X 10(5) reference units/ml. Protective efficacy demonstrated with lower concentrations of HuIFN-gamma in combination with low titers of HuIFN-alpha provided evidence of synergistic interferon activity in vivo. Tolerance problems observed in eyes affected by virus inoculation seem to be attributable to the experimental conditions including species heterology.

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Year:  1985        PMID： 3929044     DOI： 10.1007/bf02123229

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  14 in total

1.  Evidence that types I and II interferons have different receptors.

Authors:  A A Branca; C Baglioni
Journal:  Nature       Date:  1981-12-24       Impact factor: 49.962

2.  Expression of human immune interferon cDNA in E. coli and monkey cells.

Authors:  P W Gray; D W Leung; D Pennica; E Yelverton; R Najarian; C C Simonsen; R Derynck; P J Sherwood; D M Wallace; S L Berger; A D Levinson; D V Goeddel
Journal:  Nature       Date:  1982-02-11       Impact factor: 49.962

3.  Synergistic antiviral and antiproliferative activities of Escherichia coli-derived human alpha, beta, and gamma interferons.

Authors:  C W Czarniecki; C W Fennie; D B Powers; D A Estell
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

4.  Construction of expression plasmids producing high levels of human leukocyte-type interferon in Escherichia coli.

Authors:  E Dworkin-Rastl; P Swetly; M B Dworkin
Journal:  Gene       Date:  1983-03       Impact factor: 3.688

5.  Human leukocyte and fibroblast interferon in a combination therapy of dendritic keratitis.

Authors:  R Sundmacher; K Cantell; R Skoda; C Hallermann; D Neumann-Haefelin
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1978-11-30

6.  Requirement for IFN gamma in potentiation of interferon's antiviral and anticellular activities: identity of mouse and human systems.

Authors:  W R Fleischmann; L A Schwarz; C M Fleischmann
Journal:  J Interferon Res       Date:  1984

7.  Successful treatment of dendritic keratitis with human leukocyte interferon. A controlled clinical study.

Authors:  R Sundmacher; D Neumann-Haefelin; K Cantell
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1976-11-18

8.  Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.

Authors:  D Neumann-Haefelin; R Sundmacher; R Skoda; K Cantell
Journal:  Infect Immun       Date:  1977-08       Impact factor: 3.441

9.  Immunoassay for the quantitation of human leukocyte interferon.

Authors:  W Berthold; W Merk; G R Adolf
Journal:  Arzneimittelforschung       Date:  1985

10.  A unique set of polypeptides is induced by gamma interferon in addition to those induced in common with alpha and beta interferons.

Authors:  J Weil; C J Epstein; L B Epstein; J J Sedmak; J L Sabran; S E Grossberg
Journal:  Nature       Date:  1983-02-03       Impact factor: 49.962
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  4 in total

1.  Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1.

Authors:  Bruno Sainz; William P Halford
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

2.  Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea.

Authors:  Bobbie Ann Austin; William P Halford; Bryan R G Williams; Daniel J J Carr
Journal:  J Immunol       Date:  2007-04-15       Impact factor: 5.422

3.  Topical antisense-oligonucleotides targeting IFN-gamma mRNA improve incidence and severity of herpetic stromal keratitis by cytokine specific and sequence unspecific effects.

Authors:  Susanne Wasmuth; Dirk Bauer; Klaus-Peter Steuhl; Arnd Heiligenhaus
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2007-11-21       Impact factor: 3.117

4.  Innate and adaptive immune responses to herpes simplex virus.

Authors:  Tracy Chew; Kathryne E Taylor; Karen L Mossman
Journal:  Viruses       Date:  2009-11-18       Impact factor: 5.048
  4 in total

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