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Literature DB >> 793437

Successful treatment of dendritic keratitis with human leukocyte interferon. A controlled clinical study.

R Sundmacher, D Neumann-Haefelin, K Cantell.

Abstract

There were 40 virologically confirmed cases of dendritic keratitis treated in a randomized double-blind placebo-controlled study. After thermomechanical debridement of the corneal epithelium, the patients received two drops of human leukocyte interferon (HLI) twice daily. The activity was 3 X 10(-6) units/ml. HLI significantly accelerated healing and inhibited virus shedding. It remains to be studied whether HLI will be equally effective in the prophylaxis of late herpes recurrences.

Entities: Disease Species

Mesh：

Substances：
Interferons

Year: 1976 PMID： 793437 DOI： 10.1007/bf00410146

Source DB: PubMed Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol ISSN： 0065-6100

6 in total

1. Effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas.

Authors: D Neumann-Haefelin; R Sundmacher; B Sauter; H E Karges; K F Manthey
Journal: Infect Immun Date: 1975-07 Impact factor: 3.441

2. Difference in interferon response and protection from ocular virus infection in rabbits and monkeys.

Authors: H E Kaufman; E D Ellison; Y M Centifanto
Journal: Am J Ophthalmol Date: 1972-07 Impact factor: 5.258

3. [The effect of human leukocyte interteron (HIF) on experimental viral keratitis in monkeys (author's transl)].

Authors: D Neumann-Haefelin; B Shrestha
Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol Date: 1975-07-04

4. [Herpes therapy and prophylaxis. I. A critical review (author's transl)].

Authors: R Sundmacher
Journal: Klin Monbl Augenheilkd Date: 1976-09 Impact factor: 0.700

5. Clinical trials of topical interferon therapy of ulcerative viral keratitis.

Authors: B R Jones; D J Coster; M G Falcon; K Cantell
Journal: J Infect Dis Date: 1976-06 Impact factor: 5.226

6. Interferon in treatment of dendritic keratitis in humans: a preliminary report.

Authors: R Sundmacher; D Neumann-Haefelin; K F Manthey; O Müller
Journal: J Infect Dis Date: 1976-06 Impact factor: 5.226

6 in total

14 in total

Review 1. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Authors: Kirk R Wilhelmus
Journal: Cochrane Database Syst Rev Date: 2015-01-09

Review 2. Interferons: anti-neoplastic drugs?

Authors: H Strander
Journal: Blut Date: 1977-09-18

3. Recombinant HuIFN-gamma prevents herpes simplex keratitis in African green monkeys: demonstration of synergism with recombinant HuIFN-alpha 2.

Authors: D Neumann-Haefelin; R Sundmacher; H Frey; W Merk
Journal: Med Microbiol Immunol Date: 1985 Impact factor: 3.402

10. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.

Authors: D Neumann-Haefelin; R Sundmacher; R Skoda; K Cantell
Journal: Infect Immun Date: 1977-08 Impact factor: 3.441

Successful treatment of dendritic keratitis with human leukocyte interferon. A controlled clinical study.

1. Effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas.

2. Difference in interferon response and protection from ocular virus infection in rabbits and monkeys.

3. [The effect of human leukocyte interteron (HIF) on experimental viral keratitis in monkeys (author's transl)].

4. [Herpes therapy and prophylaxis. I. A critical review (author's transl)].

5. Clinical trials of topical interferon therapy of ulcerative viral keratitis.

6. Interferon in treatment of dendritic keratitis in humans: a preliminary report.

Review 1. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Review 2. Interferons: anti-neoplastic drugs?

3. Recombinant HuIFN-gamma prevents herpes simplex keratitis in African green monkeys: demonstration of synergism with recombinant HuIFN-alpha 2.

Review 4. Interferon: therapeutic fact or fiction for the '80s?

5. Role of debridement and interferon in the treatment of dendritic keratitis.

6. Biosynthetic human interferon treatment of herpetic keratitis.

Review 7. Interferons and interferon inducers: development of clinical usefulness and therapeutic promise.

8. Human leukocyte and fibroblast interferon in a combination therapy of dendritic keratitis.

Review 9. Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host?

10. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.