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Literature DB >> 4018023

Structure and expression of the human haptoglobin locus.

G Bensi, G Raugei, H Klefenz, R Cortese.

Abstract

Human genomic clones of the haptoglobin Hp1F and the "haptoglobin related' gene (Hpr) have been isolated. The two genes are adjacent, spanning a region of approximately 21 kb. A comparison of their coding sequences shows that Hpr differs from Hp1F at 28 codons. Northern blot and primer elongation analyses with human liver RNA show that the haptoglobin gene Hp1F appears to be transcribed some 1000-fold less in fetal than in adult liver. In adult liver the amount of Hpr mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the Hp1F gene. No Hpr mRNA can be detected in fetal liver.

Entities: Chemical

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Year: 1985 PMID： 4018023 PMCID： PMC554159 DOI： 10.1002/j.1460-2075.1985.tb02325.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

21 in total

Structure and expression of the human haptoglobin locus.

1. In vitro packaging of lambda and cosmid DNA.

2. Methylation of single-stranded DNA in vitro introduces new restriction endonuclease cleavage sites.

3. Base sequence studies of 300 nucleotide renatured repeated human DNA clones.

4. Common and interchangeable elements in the promoters of genes transcribed by RNA polymerase iii.

5. Gene shuttling: moving of cloned DNA into and out of eukaryotic cells.

6. The ovalbumin gene-sequence of putative control regions.

7. Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates.

8. Cloning of nematode tRNA genes and their expression in the frog oocyte.

9. DNA sequencing with chain-terminating inhibitors.

10. Studies on transformation of Escherichia coli with plasmids.

1. Structural characterization of a rice actin gene.

2. Promoter of the pertussis toxin operon and production of pertussis toxin.

3. Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.

4. Structure of the human hemopexin gene and evidence for intron-mediated evolution.

5. A new restriction fragment length polymorphism in the haptoglobin gene region.

6. Molecular evidence of triplication in the haptoglobin Johnson variant gene.

7. A population genetic survey of the haptoglobin polymorphism in Melanesians by DNA analysis.

8. Structure of gene and pseudogenes of human apoferritin H.

9. The haptoglobin-gene deletion responsible for anhaptoglobinemia.

10. Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression.