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Literature DB >> 2993157

Molecular evidence of triplication in the haptoglobin Johnson variant gene.

S Oliviero, M DeMarchi, A O Carbonara, L F Bernini, G Bensi, G Raugei.

Abstract

The protein and gene structure of the Hp Johnson variant (Hp3) were analyzed in two related heterozygous individuals. The molecular weight (23 kd) and amino acid composition of Hp3 alpha chain were in agreement with the triplicated structure first suggested by Smithies in 1964. Direct gene analysis by Southern blotting showed a three-fold tandem repeat of the same 1.7 kb DNA segment implicated in the Hp2 gene duplication. On the basis of these data a nine exon model for the Hp3 gene is proposed.

Entities: Gene

Mesh：

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Year: 1985 PMID： 2993157 DOI： 10.1007/bf00295668

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

14 in total

3. Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene.

Authors: S Marinković; H Baumann
Journal: Mol Cell Biol Date: 1990-04 Impact factor: 4.272

4. The human haptoglobin gene: transcriptional regulation during development and acute phase induction.

Authors: S Oliviero; G Morrone; R Cortese
Journal: EMBO J Date: 1987-07 Impact factor: 11.598

Review 5. A review of haptoglobin typing methods for disease association study and preventing anaphylactic transfusion reaction.

Authors: Dae-Hyun Ko; Ho Eun Chang; Taek Soo Kim; Eun Young Song; Kyoung Un Park; Junghan Song; Kyou Sup Han
Journal: Biomed Res Int Date: 2013-02-28 Impact factor: 3.411

5 in total

Molecular evidence of triplication in the haptoglobin Johnson variant gene.

1. Reaction of reduced disulfide bonds in alpha-lactalbumin and beta-lactoglobulin with acrylonitrile.

2. CHROMOSOMAL REARRANGEMENTS AND PROTEIN STRUCTURE.

3. Haptoglobin sub-types in three racial groups.

4. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

5. Hydrolysis of proteins with p-toluenesulfonic acid. Determination of tryptophan.

6. Duplication within the haptoglobin Hp2 gene.

7. Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA.

8. Identification and characterization of human haptoglobin cDNA.

Review 9. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation.

10. Molecular cloning of human haptoglobin cDNA: evidence for a single mRNA coding for alpha 2 and beta chains.

1. The haptoglobin-gene deletion responsible for anhaptoglobinemia.

2. The phosphocreatine shuttle of sea urchin sperm: flagellar creatine kinase resulted from a gene triplication.

3. Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene.

4. The human haptoglobin gene: transcriptional regulation during development and acute phase induction.

Review 5. A review of haptoglobin typing methods for disease association study and preventing anaphylactic transfusion reaction.