Literature DB >> 3920080

Congenital jaundice in rats due to the absence of hepatic bilirubin UDP-glucuronyltransferase enzyme protein.

I Scragg, C Celier, B Burchell.   

Abstract

Three major UDP-glucuronyltransferase isoenzymes (50-54 kDa) have been identified by immunoblot analysis. Bilirubin UDP-glucuronyltransferase (54 kDa) was specially induced by treatment of the rats with clofibrate. This isoenzyme was not detectable in liver microsomal extracts from congenitally jaundiced Gunn rats and was not induced by treatment of these animals with clofibrate. Phenol UDP-glucuronyltransferase, the only isoenzyme determined to be present in foetal Wistar rat liver microsomes was not detected by enzyme assay or immunoblot analysis of foetal Gunn rat liver microsomal extracts. These results provide the first indication that bilirubin UDP-glucuronyltransferase and possible phenol UDP-glucuronyltransferase proteins are not present in the congenitally jaundiced Gunn rat.

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Year:  1985        PMID： 3920080     DOI： 10.1016/0014-5793(85)80949-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Multiplicity of UDP-glucuronosyltransferases in fish. Purification and characterization of a phenol UDP-glucuronosyltransferase from the liver of a marine teleost, Pleuronectes platessa.

Authors:  D J Clarke; S G George; B Burchell
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

2.  Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA.

Authors:  M R Jackson; L R McCarthy; D Harding; S Wilson; M W Coughtrie; B Burchell
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857

3.  Development of multiple activities of UDP-glucuronyltransferase in human liver.

Authors:  J E Leakey; R Hume; B Burchell
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

4.  Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver.

Authors:  H Yokota; H Iwano; M Endo; T Kobayashi; H Inoue; S Ikushiro; A Yuasa
Journal:  Biochem J       Date:  1999-06-01       Impact factor: 3.857

5.  The full length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family.

Authors:  M R Jackson; B Burchell
Journal:  Nucleic Acids Res       Date:  1986-01-24       Impact factor: 16.971

6.  Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene (Gnt-1) to chromosome 1 by restriction fragment length variations.

Authors:  H Sato; Y Sakai; O Koiwai; T Watanabe
Journal:  Biochem Genet       Date:  1992-08       Impact factor: 1.890

Review 7.  The role of conjugation reactions in detoxication.

Authors:  K W Bock; W Lilienblum; G Fischer; G Schirmer; B S Bock-Henning
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

8.  Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.

Authors:  J Kapitulnik; J P Hardwick; J D Ostrow; C C Webster; S S Park; H V Gelboin
Journal:  Biochem J       Date:  1987-02-15       Impact factor: 3.857

9.  Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats.

Authors:  L Braun; M J Coffey; F Puskás; T Kardon; G Nagy; A A Conley; B Burchell; J Mandl
Journal:  Biochem J       Date:  1998-12-15       Impact factor: 3.857

10.  Studies on the genetic linkage of bilirubin and androsterone UDP-glucuronyltransferases by cross-breeding of two mutant rat strains.

Authors:  F Nagai; H Homma; H Tanase; M Matsui
Journal:  Biochem J       Date:  1988-06-15       Impact factor: 3.857
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