Literature DB >> 9841869

Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats.

L Braun1, M J Coffey, F Puskás, T Kardon, G Nagy, A A Conley, B Burchell, J Mandl.   

Abstract

The co-ordinated induction of several hepatic drug-metabolizing enzymes is a common feature in the regulation of drug biotransformation under normal and pathological conditions. In the present study the activity and expression of bilirubin UDP-glucuronosyltransferase (UGT1A1) were investigated in livers of BioBreeding/Worcester diabetic, fasted and acetone-treated rats. Bilirubin glucuronidation was stimulated by all three treatments; this was correlated with an increase in the UGT1A1 protein concentration in hepatic microsomes. Transcriptional induction of UGT1A1 was also observed in diabetes and starvation but not with acetone treatment, which apparently caused translational stabilization of the enzyme protein. The hormonal/metabolic alterations in diabetes and starvation might be a model for postnatal development. The sudden interruption of maternal glucose supply signals the enhanced expression of UGT1A1, giving a novel explanation for the physiological induction of bilirubin glucuronidation in newborn infants.

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Year:  1998        PMID： 9841869      PMCID： PMC1219908          DOI： 10.1042/bj3360587

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  30 in total

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Journal:  Experientia       Date:  1971-01-15

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Journal:  Biochem Pharmacol       Date:  1980-09-01       Impact factor: 5.858

7.  Reconstitution of purified Wistar rat liver bilirubin UDP-glucuronyltransferase into Gunn-rat liver microsomes.

Authors:  B Burchell
Journal:  Biochem J       Date:  1982-03-01       Impact factor: 3.857

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Authors:  D Samson; D Halliday; I Chanarin
Journal:  Lancet       Date:  1976-07-31       Impact factor: 79.321

9.  Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver.

Authors:  B Burchell
Journal:  Biochem J       Date:  1978-09-01       Impact factor: 3.857

10.  Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.

Authors:  E N Lalani; B Burchell
Journal:  Biochem J       Date:  1979-03-01       Impact factor: 3.857
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  6 in total

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4.  The effect of bamboo extract on hepatic biotransforming enzymes--findings from an obese-diabetic mouse model.

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5.  Influence of gestational diabetes mellitus on the stereoselective kinetic disposition and metabolism of labetalol in hypertensive patients.

Authors:  Teresa Maria J P Carvalho; Ricardo de Carvalho Cavalli; Sérgio P Cunha; Cláudia O de Baraldi; Maria P Marques; Natalícia J Antunes; Ana Leonor P C Godoy; Vera Lucia Lanchote
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Review 6.  The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.

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  6 in total

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