Literature DB >> 3593244

Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.

J Kapitulnik, J P Hardwick, J D Ostrow, C C Webster, S S Park, H V Gelboin.   

Abstract

Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3593244      PMCID： PMC1147698          DOI： 10.1042/bj2420297

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

1.  Characterization of the major diazo-positive pigments in bile of homozygous Gunn rats.

Authors:  N Blanckaert; J Fevery; K P Heirwegh; F Compernolle
Journal:  Biochem J       Date:  1977-04-15       Impact factor: 3.857

2.  Evidence for conversion of bilirubin to dihydroxyl derivatives in the gunn rat.

Authors:  C S Berry; J E Zarembo; J D Ostrow
Journal:  Biochem Biophys Res Commun       Date:  1972-12-04       Impact factor: 3.575

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.

Authors:  S S Park; T Fujino; D West; F P Guengerich; H V Gelboin
Journal:  Cancer Res       Date:  1982-05       Impact factor: 12.701

5.  Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes.

Authors:  D J Waxman; G A Dannan; F P Guengerich
Journal:  Biochemistry       Date:  1985-07-30       Impact factor: 3.162

6.  Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues.

Authors:  J A Goldstein; P Linko
Journal:  Mol Pharmacol       Date:  1984-01       Impact factor: 4.436

7.  Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

Authors:  F J Gonzalez; B J Song; J P Hardwick
Journal:  Mol Cell Biol       Date:  1986-08       Impact factor: 4.272

8.  Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response.

Authors:  J P Hardwick; F J Gonzalez; C B Kasper
Journal:  J Biol Chem       Date:  1983-08-25       Impact factor: 5.157

9.  Congenital jaundice in rats due to the absence of hepatic bilirubin UDP-glucuronyltransferase enzyme protein.

Authors:  I Scragg; C Celier; B Burchell
Journal:  FEBS Lett       Date:  1985-04-08       Impact factor: 4.124

10.  Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.

Authors:  P E Thomas; L M Reik; D E Ryan; W Levin
Journal:  J Biol Chem       Date:  1983-04-10       Impact factor: 5.157
View more
  3 in total

1.  Effects of hyperbilirubinaemia on glutathione S-transferase isoenzymes in cerebellar cortex of the Gunn rat.

Authors:  J A Johnson; J J Hayward; S E Kornguth; F L Siegel
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

2.  Transport and metabolism at blood-brain interfaces and in neural cells: relevance to bilirubin-induced encephalopathy.

Authors:  Silvia Gazzin; Nathalie Strazielle; Claudio Tiribelli; Jean-François Ghersi-Egea
Journal:  Front Pharmacol       Date:  2012-05-18       Impact factor: 5.810

3.  Enhancing effect of a choline-deficient diet on alterations of hepatic drug-metabolizing enzymes in hepatitis- and hepatoma-predisposed rats (LEC rats).

Authors:  T Sugiyama; M Matsunaga; S K Jain; S Jain; Y Ikeda; N Taniguchi
Journal:  Jpn J Cancer Res       Date:  1991-04
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.