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Literature DB >> 3109396

Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA.

M R Jackson, L R McCarthy, D Harding, S Wilson, M W Coughtrie, B Burchell.

Abstract

A cDNA clone (HLUG 25) encoding the complete sequence of a human liver UDP-glucuronosyltransferase was isolated from a lambda gt11 human liver cDNA library. The library was screened by hybridization to a partial-length human UDP-glucuronosyltransferase cDNA (pHUDPGT1) identified from a human liver pEX cDNA expression library by using anti-UDP-glucuronosyltransferase antibodies. The authenticity of the cDNA clone was confirmed by hybrid-select translation and extensive sequence homology to rat liver UDP-glucuronosyltransferase cDNAs. The sequence of HLUG 25 cDNA was determined to be 2104 base-pairs long, including a poly(A) tail, and contains a long open reading frame. The possible site of translation initiation of this sequence is discussed with reference to a rat UDP-glucuronosyltransferase cDNA clone (RLUG 38).

Entities: Gene Species

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Year: 1987 PMID： 3109396 PMCID： PMC1147744 DOI： 10.1042/bj2420581

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

42 in total

1. Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase.

Authors: J Roy Chowdhury; N Roy Chowdhury; C N Falany; T R Tephly; I M Arias
Journal: Biochem J Date: 1986-02-01 Impact factor: 3.857

2. Hypervariable 'minisatellite' regions in human DNA.

Authors: A J Jeffreys; V Wilson; S L Thein
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3. Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC.

Authors: Y Yabusaki; M Shimizu; H Murakami; K Nakamura; K Oeda; H Ohkawa
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4. A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems.

Authors: C S Yost; J Hedgpeth; V R Lingappa
Journal: Cell Date: 1983-10 Impact factor: 41.582

5. The biosynthesis and induction of microsomal UDP-glucuronyltransferase in avian liver.

Authors: B Burchell; S Kennedy; M Jackson; L McCarthy
Journal: Biochem Soc Trans Date: 1984-02 Impact factor: 5.407

6. Quantitation of rabbit cytochrome P-450, form 2, in microsomal preparations bound directly to nitrocellulose paper using a modified peroxidase-immunostaining procedure.

Authors: B A Domin; C J Serabjit-Singh; R M Philpot
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

7. Cleavage of nascent UDP glucuronosyltransferase from rat liver by dog pancreatic microsomes.

Authors: P I Mackenzie; I S Owens
Journal: Biochem Biophys Res Commun Date: 1984-08-16 Impact factor: 3.575

8. Gene transfer and expression of human phenylalanine hydroxylase.

Authors: F D Ledley; H E Grenett; A G DiLella; S C Kwok; S L Woo
Journal: Science Date: 1985-04-05 Impact factor: 47.728

9. Congenital jaundice in rats due to the absence of hepatic bilirubin UDP-glucuronyltransferase enzyme protein.

Authors: I Scragg; C Celier; B Burchell
Journal: FEBS Lett Date: 1985-04-08 Impact factor: 4.124

10. Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins.

Authors: K K Stanley; J P Luzio
Journal: EMBO J Date: 1984-06 Impact factor: 11.598

21 in total

1. Regulation of expression of a baculovirus ecdysteroid UDPglucosyltransferase gene.

Authors: D R O'Reilly; L K Miller
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2. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family.

Authors: R Wooster; L Sutherland; T Ebner; D Clarke; O Da Cruz e Silva; B Burchell
Journal: Biochem J Date: 1991-09-01 Impact factor: 3.857

3. Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I.

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Journal: J Clin Invest Date: 1990-04 Impact factor: 14.808

4. Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase.

Authors: G Monaghan; B Burchell; M Boxer
Journal: Mamm Genome Date: 1997-09 Impact factor: 2.957

5. Nucleotide and deduced amino acid sequence of rat liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase.

Authors: D Harding; S M Wilson; M R Jackson; B Burchell; M D Green; T R Tephly
Journal: Nucleic Acids Res Date: 1987-05-11 Impact factor: 16.971

6. Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

Authors: D Harding; S Fournel-Gigleux; M R Jackson; B Burchell
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

7. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector.

Authors: Gabriele Toietta; Viraj P Mane; Wilma S Norona; Milton J Finegold; Philip Ng; Antony F McDonagh; Arthur L Beaudet; Brendan Lee
Journal: Proc Natl Acad Sci U S A Date: 2005-03-07 Impact factor: 11.205

8. Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1.

Authors: Adam G Staines; Pavel Sindelar; Michael W H Coughtrie; Brian Burchell
Journal: Biochem J Date: 2004-12-15 Impact factor: 3.857

9. Functional expression of zeaxanthin glucosyltransferase from Erwinia herbicola and a proposed uridine diphosphate binding site.

Authors: B S Hundle; D A O'Brien; M Alberti; P Beyer; J E Hearst
Journal: Proc Natl Acad Sci U S A Date: 1992-10-01 Impact factor: 11.205

10. Expression of human liver epoxide hydrolase in Saccharomyces pombe.

Authors: M R Jackson; B Burchell
Journal: Biochem J Date: 1988-05-01 Impact factor: 3.857