Literature DB >> 3918310

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

M Wabl, P D Burrows, A von Gabain, C Steinberg.   

Abstract

Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) per cell generation. This high rate is termed hypermutation.

Mesh：

Substances：

Year:  1985        PMID： 3918310      PMCID： PMC397062          DOI： 10.1073/pnas.82.2.479

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

Authors:  H Hengartner; T Meo; E Müller
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  The frequency distribution of spontaneous bacteriophage mutants as evidence for the exponential rate of phage reproduction.

Authors:  S E LURIA
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1951

3.  J genes for heavy chain immunoglobulins of mouse.

Authors:  N Newell; J E Richards; P W Tucker; F R Blattner
Journal:  Science       Date:  1980-09-05       Impact factor: 47.728

4.  Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells.

Authors:  I G Haas; M R Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

5.  Somatic cell genetics of antibody-secreting cells: studies of clonal diversification and analysis by cell fusion.

Authors:  C Milstein; K Adetugbo; N J Cowan; G Köhler; D S Secher; C D Wilde
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

6.  Somatic mutants and antibody diversity.

Authors:  D S Secher; C Milstein; K Adetugbo
Journal:  Immunol Rev       Date:  1977       Impact factor: 12.988

7.  Inheritance of spontaneous mutability in yeast.

Authors:  R C Von Borstel; K T Cain; C M Steinberg
Journal:  Genetics       Date:  1971-09       Impact factor: 4.562

8.  Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus.

Authors:  E J Siden; D Baltimore; D Clark; N E Rosenberg
Journal:  Cell       Date:  1979-02       Impact factor: 41.582

9.  Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.

Authors:  T Meo; J Johnson; C V Beechey; S J Andrews; J Peters; A G Searle
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
View more
  50 in total

Review 1.  In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.

Authors:  J E Sale; M Bemark; G T Williams; C J Jolly; M R Ehrenstein; C Rada; C Milstein; M S Neuberger
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

2.  An experimental solution for the Luria-Delbrück fluctuation problem in measuring hypermutation rates.

Authors:  J Bachl; M Dessing; C Olsson; R C von Borstel; C Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

3.  Genome-wide somatic hypermutation.

Authors:  Clifford L Wang; Ryan A Harper; Matthias Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-29       Impact factor: 11.205

4.  Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.

Authors:  Michael E Abram; Andrea L Ferris; Wei Shao; W Gregory Alvord; Stephen H Hughes
Journal:  J Virol       Date:  2010-07-21       Impact factor: 5.103

5.  Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines.

Authors:  M Zhu; N S Green; J L Rabinowitz; M D Scharff
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

6.  Molecular analysis of neonatal IgA expression: implications for class switching, allelic polymorphism and somatic mutation.

Authors:  S L Jones; J M Teale; S C Riley; N R Klinman; P W Tucker
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

7.  Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.

Authors:  Michael E Abram; Andrea L Ferris; Kalyan Das; Octavio Quinoñes; Wei Shao; Steven Tuske; W Gregory Alvord; Eddy Arnold; Stephen H Hughes
Journal:  J Virol       Date:  2014-04-23       Impact factor: 5.103

8.  Differences in mutagenesis during minus strand, plus strand and strand transfer (recombination) synthesis of the HIV-1 gene in vitro.

Authors:  W Wu; C Palaniappan; R A Bambara; P J Fay
Journal:  Nucleic Acids Res       Date:  1996-05-01       Impact factor: 16.971

9.  The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.

Authors:  J Bachl; C Olsson; N Chitkara; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

10.  Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells.

Authors:  H Kiyoi; T Naoe; K Horibe; R Ohno
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.