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Literature DB >> 3898282

Thymopentin structure and relation to thymic factors.

Abstract

High-performance liquid chromatography (HPLC) was used to evaluate the purity and batch-to-batch consistency of four commercially available thymic extracts and thymopentin, the synthetic pentapeptide corresponding to the biologically active region of the thymic hormone thymopoietin. The thymus extracts were all extremely heterogeneous, differing one from the other. Additionally, they showed high batch-to-batch variation. In contrast, thymopentin was homogeneous and this homogeneity was consistent in different batches.

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Year: 1985 PMID： 3898282 DOI： 10.1007/bf02919051

Source DB: PubMed Journal: Surv Immunol Res ISSN： 0252-9564

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References

10 in total

1. The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus.

Authors: T L Low; G B Thurman; M McAdoo; J McClure; J L Rossio; P H Naylor; A L Goldstein
Journal: J Biol Chem Date: 1979-02-10 Impact factor: 5.157

2. Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

Authors: G Goldstein; M Scheid; U Hammerling; D H Schlesinger; H D Niall; E A Boyse
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

3. Structural study of circulating thymic factor: a peptide isolated from pig serum. II. Amino acid sequence.

Authors: J M Pleau; M Dardenne; Y Blouquit; J F Bach
Journal: J Biol Chem Date: 1977-11-25 Impact factor: 5.157

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Authors: M M Solov'ev; A V Vasil'ev; V G Morozov; V Kh Khavinson; V V Titov
Journal: Biull Eksp Biol Med Date: 1977-09

5. Isolation and partial chemical characterization of THF, a thymus hormone involved in immune maturation of lymphoid cells.

Authors: A I Kook; Y Yakir; N Trainin
Journal: Cell Immunol Date: 1975-09 Impact factor: 4.868

Thymopentin structure and relation to thymic factors.

1. The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus.

2. Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

3. Structural study of circulating thymic factor: a peptide isolated from pig serum. II. Amino acid sequence.

4. [Influence of physiologically active substances isolated from the thymus on the course of the wound process following cryodestruction in rats].

5. Isolation and partial chemical characterization of THF, a thymus hormone involved in immune maturation of lymphoid cells.

6. Evaluation of biological activity of TFX (Polfa) a product obtained from calf thymus.

7. Isolation of bovine thymin: a polypeptide hormone of the thymus.

8. Complete amino acid sequences of bovine thymopoietins I, II, and III: closely homologous polypeptides.

9. A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin.

10. Distribution of prothymosin alpha in rat tissues.