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Literature DB >> 1078892

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

G Goldstein, M Scheid, U Hammerling, D H Schlesinger, H D Niall, E A Boyse.

Abstract

A polypeptide of 8500 molecular weight is described that induces the differentiation of T (thymus-derived) cell and B (bone-marrow-derived) cell immunocytes in vitro, apparently via beta-adrenergic receptors and adenylate cyclase activation. This polypeptide shows a high degree of evolutionary conservation, exhibiting close structural, functional, and immunological similarity when isolated from such diverse origins as cells of mammals and higher plants. This polypeptide was detected in animal cells, yeast, bacteria, and higher plants, and so may well be a universal constituent of living cells.

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Year: 1975 PMID： 1078892 PMCID： PMC432229 DOI： 10.1073/pnas.72.1.11

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors: W M HUNTER; F C GREENWOOD
Journal: Nature Date: 1962-05-05 Impact factor: 49.962

2. Translational diffusion coefficient and partition coefficient of a spin-labeled solute in lecithin bilayer membranes.

Authors: J A Dix; J M Diamond; D Kivelson
Journal: Proc Natl Acad Sci U S A Date: 1974-02 Impact factor: 11.205

3. In-vitro demonstration of thymic hormone in the mouse by conversion of precursor cells into lymphocytes.

Authors: K Komuro; E A Boyse
Journal: Lancet Date: 1973-04-07 Impact factor: 79.321

4. Isolation of bovine thymin: a polypeptide hormone of the thymus.

Authors: G Goldstein
Journal: Nature Date: 1974-01-04 Impact factor: 49.962

5. Human lymphocyte-dependent antibody mediated cytotoxicity and direct lymphocyte cytotoxicity against non-HL-A antigens.

Authors: I Yust; J Wunderlich; D L Mann; G N Rogentine; B Leventhal; R Yankee; R Graw
Journal: Nature Date: 1974-05-17 Impact factor: 49.962

6. Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.

Authors: S Avrameas
Journal: Immunochemistry Date: 1969-01

7. The thymus and neuromuscular function. A substance in thymus which causes myositis and myasthenic neuromuscular block in guineapigs.

Authors: G Goldstein
Journal: Lancet Date: 1968-07-20 Impact factor: 79.321

8. Differentiation of T cells induced by preparations from thymus and by nonthymic agents.

Authors: M P Scheid; M K Hoffmann; K Komuro; U Hämmerling; J Abbott; E A Boyse; G H Cohen; J A Hooper; R S Schulof; A L Goldstein
Journal: J Exp Med Date: 1973-10-01 Impact factor: 14.307

9. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization.

Authors: C Bianco; R Patrick; V Nussenzweig
Journal: J Exp Med Date: 1970-10-01 Impact factor: 14.307

10. Induction of T lymphocytes from precursor cells in vitro by a product of the thymus.

Authors: K Komuro; E A Boyse
Journal: J Exp Med Date: 1973-08-01 Impact factor: 14.307

159 in total

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