[Influence of physiologically active substances isolated from the thymus on the course of the wound process following cryodestruction in rats].

Experiments were conducted on 40 male albino rats subjected to general irradiation in a dose of 200 R, to study the influence of "thymarin"--a compound obtained from the thymus of cattle (representing a complex of three physiologically active polypeptide fractions with an average mol wt 10 000) on the course of local wound process after cryodestruction of the hard palate mucosa. The preparation was injected subcutaneously for ten days after cryodestruction. The experimental data obtained pointed to a favourable influence of "thymarin" on the course of regenerative processes, as shown by accelerated rejection of necrotic tissues, more rapid epithelialization of wound surface, and prevention of secondary infection.