Literature DB >> 3859205

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

G M Lathrop, J M Lalouel, C Julier, J Ott.   

Abstract

Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a linkage group. We consider the appropriateness of assuming no interference with data available in human genetic studies. Examples are given to show the significance of multilocus analysis in humans. A computer program package, LINKAGE, for multilocus linkage analysis is described.

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Year:  1985        PMID： 3859205      PMCID： PMC1684598     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  16 in total

1.  Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees.

Authors:  K Lange; R C Elston
Journal:  Hum Hered       Date:  1975       Impact factor: 0.444

2.  A mapping function for human chromosomes.

Authors:  E Sturt
Journal:  Ann Hum Genet       Date:  1976-11       Impact factor: 1.670

3.  Linkage group I: the simultaneous estimation of recombination and interference.

Authors:  D A Meyers; P M Conneally; E W Lovrien; R E Magenis; A D Merritt; J A Norton; C G Palmer; M L Rivas; L Wang; P L Yu
Journal:  Birth Defects Orig Artic Ser       Date:  1976

4.  A mathematically tractable family of genetic mapping functions with different amounts of interference.

Authors:  J Felsenstein
Journal:  Genetics       Date:  1979-04       Impact factor: 4.562

5.  A general model for the genetic analysis of pedigree data.

Authors:  R C Elston; J Stewart
Journal:  Hum Hered       Date:  1971       Impact factor: 0.444

6.  Statistical analysis of multilocus recombination.

Authors:  N Risch; K Lange
Journal:  Biometrics       Date:  1983-12       Impact factor: 2.571

7.  An alternative model of recombination and interference.

Authors:  N Risch; K Lange
Journal:  Ann Hum Genet       Date:  1979-07       Impact factor: 1.670

8.  A mapping function for man.

Authors:  D C Rao; N E Morton; J Lindsten; M Hultén; S Yee
Journal:  Hum Hered       Date:  1977       Impact factor: 0.444

9.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

Review 10.  Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors:  D Botstein; R L White; M Skolnick; R W Davis
Journal:  Am J Hum Genet       Date:  1980-05       Impact factor: 11.025
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  514 in total

1.  Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.

Authors:  C S Jensen; A Kong
Journal:  Am J Hum Genet       Date:  1999-09       Impact factor: 11.025

2.  The gene for cherubism maps to chromosome 4p16.

Authors:  V Tiziani; E Reichenberger; C L Buzzo; S Niazi; N Fukai; M Stiller; H Peters; F M Salzano; C M Raposo do Amaral; B R Olsen
Journal:  Am J Hum Genet       Date:  1999-07       Impact factor: 11.025

3.  Identification of a new locus for generalized epilepsy with febrile seizures plus (GEFS+) on chromosome 2q24-q33.

Authors:  B Moulard; M Guipponi; D Chaigne; D Mouthon; C Buresi; A Malafosse
Journal:  Am J Hum Genet       Date:  1999-11       Impact factor: 11.025

4.  A second locus for an axonal form of autosomal recessive Charcot-Marie-Tooth disease maps to chromosome 19q13.3.

Authors:  A Leal; B Morera; D Heuss; C Kayser; M Berghoff; R Villegas; E Hernández; M Méndez; H C Hennies; B Neundörfer; R Barrantes; A Reis; B Rautenstrauss
Journal:  Am J Hum Genet       Date:  2000-12-07       Impact factor: 11.025

5.  A gene for X-linked idiopathic congenital nystagmus (NYS1) maps to chromosome Xp11.4-p11.3.

Authors:  A Cabot; J M Rozet; S Gerber; I Perrault; D Ducroq; A Smahi; E Souied; A Munnich; J Kaplan
Journal:  Am J Hum Genet       Date:  1999-04       Impact factor: 11.025

6.  Identifying disease genes underlying complex traits.

Authors:  Mark L Johnson
Journal:  Clin Rev Allergy Immunol       Date:  2002-02       Impact factor: 8.667

7.  Exclusion of the Nurr1 gene in autosomal recessive Parkinson's disease.

Authors:  Nina Rawal; Magali Periquet; Alexandra Dürr; Giuseppe de Michele; Vincenzo Bonifati; Helio A Teive; Salmo Raskin; Joao Guimaraes; Yves Agid; Alexis Brice
Journal:  J Neurol       Date:  2002-08       Impact factor: 4.849

8.  Familial cavernous malformations in a large French kindred: mapping of the gene to the CCM1 locus on chromosome 7q.

Authors:  L Notelet; F Chapon; S Khoury; K Vahedi; J P Chodkiewicz; P Courtheoux; M T Iba-Zizen; E A Cabanis; B Lechevalier; E Tournier-Lasserve; J P Houtteville
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-07       Impact factor: 10.154

9.  Genetic linkage and heterogeneity in type I Charcot-Marie-Tooth disease (hereditary motor and sensory neuropathy type I).

Authors:  P F Chance; T D Bird; P O'Connell; H Lipe; J M Lalouel; M Leppert
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025

10.  Dominant X linked subcortical laminar heterotopia and lissencephaly syndrome (XSCLH/LIS): evidence for the occurrence of mutation in males and mapping of a potential locus in Xq22.

Authors:  V des Portes; J M Pinard; D Smadja; J Motte; O Boespflüg-Tanguy; M L Moutard; I Desguerre; P Billuart; A Carrie; T Bienvenu; M C Vinet; L Bachner; C Beldjord; O Dulac; A Kahn; G Ponsot; J Chelly
Journal:  J Med Genet       Date:  1997-03       Impact factor: 6.318
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