Statistical analysis of multilocus recombination.

A general formula for the frequency of different recombinant gamete types, in terms of the underlying distribution of crossovers, is derived. This formula may be applied to any theoretical model of recombination in which it is assumed that there is no chromatid interference. Multiple-locus recombination data may be evaluated by using this formula in conjunction with a maximum likelihood procedure. The validity of any model of recombination may be tested in such a fashion. The possibilities are demonstrated through application to a generalized noninterference model of crossing over described in a previous paper (Risch and Lange, 1979, Annals of Human Genetics 43, 61-70).