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Literature DB >> 10441593

Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.

Abstract

We apply the method of "blocking Gibbs" sampling to a problem of great importance and complexity-linkage analysis. Blocking Gibbs sampling combines exact local computations with Gibbs sampling, in a way that complements the strengths of both. The method is able to handle problems with very high complexity, such as linkage analysis in large pedigrees with many loops, a task that no other known method is able to handle. New developments of the method are outlined, and it is applied to a highly complex linkage problem in a human pedigree.

Entities: Species

Mesh：

Year: 1999 PMID： 10441593 PMCID： PMC1377993 DOI： 10.1086/302524

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

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8 in total

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2. The cluster variation method for efficient linkage analysis on extended pedigrees.

Authors: Cornelis A Albers; Martijn A R Leisink; Hilbert J Kappen
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Authors: Cornelis A Albers; Tom Heskes; Hilbert J Kappen
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Authors: Cornelis A Albers; Jim Stankovich; Russell Thomson; Melanie Bahlo; Hilbert J Kappen
Journal: Am J Hum Genet Date: 2008-03 Impact factor: 11.025

8. An efficient algorithm to compute marginal posterior genotype probabilities for every member of a pedigree with loops.

Authors: Liviu R Totir; Rohan L Fernando; Joseph Abraham
Journal: Genet Sel Evol Date: 2009-12-03 Impact factor: 4.297