| Literature DB >> 360074 |
A C Chang, J H Nunberg, R J Kaufman, H A Erlich, R T Schimke, S N Cohen.
Abstract
The construction and analysis of bacterial plasmids that contain and phenotypically express a mammalian genetic sequence are described. Such plasmids specify a protein that has enzymatic properties, immunological reactivity and molecular size characteristic of the mouse dihydrofolate reductase, and render host cells resistant to the antimetabolic drug trimethoprim.Entities:
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Year: 1978 PMID： 360074 DOI： 10.1038/275617a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962