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Literature DB >> 2554584

Human topoisomerase 1 messenger RNA is not destabilized by the herpes simplex virus type 2 virion-associated shut-off function.

Abstract

A cDNA for human topoisomerase I (Topo 1) was used to identify a 4.1 kb polyadenylated Topo 1 mRNA in methotrexate-resistant human KB cells that are permissive for herpes simplex virus type 2 (HSV-2) infection. Using these cells, no effect of the HSV-2-associated early shut-off function on levels of Topo-1 mRNA was observed up to 6 hours postinfection, whereas the actin mRNA level was 22% cellular transcripts are susceptible. The level of several host-cell polyadenylated RNAs detected as cDNA clones (class 3 transcripts) were unchanged 8 hours after HSV-2 infection, and other cellular transcripts (class 2) actually accumulated at postinfection.

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Year: 1989 PMID： 2554584 DOI： 10.1007/BF00684043

Source DB: PubMed Journal: Virus Genes ISSN： 0920-8569 Impact factor: 2.332

36 in total

1. Determinants of messenger RNA stability.

Authors: G Brawerman
Journal: Cell Date: 1987-01-16 Impact factor: 41.582

2. Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4.

Authors: D S Latchman; J K Estridge; L M Kemp
Journal: Nucleic Acids Res Date: 1987-09-25 Impact factor: 16.971

3. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors: P S Thomas
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

4. Early virion-associated suppression of cellular protein synthesis by herpes simplex virus is accompanied by inactivation of mRNA.

Authors: M L Fenwick; M M McMenamin
Journal: J Gen Virol Date: 1984-07 Impact factor: 3.891

1. Effect of herpes simplex virus type-1 UL41 gene on the stability of mRNA from the cellular genes: beta-actin, fibronectin, glucose transporter-1, and docking protein, and on virus intraperitoneal pathogenicity to newborn mice.

Authors: Y Becker; E Tavor; Y Asher; C Berkowitz; M Moyal
Journal: Virus Genes Date: 1993-06 Impact factor: 2.332

1 in total

Human topoisomerase 1 messenger RNA is not destabilized by the herpes simplex virus type 2 virion-associated shut-off function.

1. Determinants of messenger RNA stability.

2. Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4.

3. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

4. Early virion-associated suppression of cellular protein synthesis by herpes simplex virus is accompanied by inactivation of mRNA.

5. cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

6. The kinetics of expression of individual herpes simplex virus type 1 transcripts.

7. The intracellular content of dihydrofolate reductase: possibilities for control and implications for chemotherapy.

8. The ribonuclease activity of crystallized pancreatic deoxyribonuclease.

9. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

10. Early and delayed shut-off of host protein synthesis in cells infected with herpes simplex virus.

1. Effect of herpes simplex virus type-1 UL41 gene on the stability of mRNA from the cellular genes: beta-actin, fibronectin, glucose transporter-1, and docking protein, and on virus intraperitoneal pathogenicity to newborn mice.