| Literature DB >> 34183859 |
Yeon Sik Choi1,2,3, Rose T Yin4, Anna Pfenniger5, Jahyun Koo1,2, Raudel Avila6, K Benjamin Lee7, Sheena W Chen7, Geumbee Lee1,2,3, Gang Li8, Yun Qiao4, Alejandro Murillo-Berlioz9, Alexi Kiss10,11, Shuling Han12,13, Seung Min Lee1, Chenhang Li6, Zhaoqian Xie14, Yu-Yu Chen15, Amy Burrell5, Beth Geist5, Hyoyoung Jeong1,2, Joohee Kim1,2, Hong-Joon Yoon1,2,3,16, Anthony Banks1,2, Seung-Kyun Kang17,18, Zheng Jenny Zhang12,13, Chad R Haney19,20, Alan Varteres Sahakian19,21, David Johnson5, Tatiana Efimova10,11, Yonggang Huang1,3,6,22, Gregory D Trachiotis9, Bradley P Knight5, Rishi K Arora23, Igor R Efimov24, John A Rogers25,26,27,28,29,30.
Abstract
Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.Entities:
Mesh：
Year: 2021 PMID： 34183859 PMCID： PMC9270064 DOI： 10.1038/s41587-021-00948-x
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 68.164